Nanotoxicology - Progress Toward Nanomedicine, Second Edition

Informationen zum Autor Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State.C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine! Edinburgh! United Kingdom. Zusammenfassung Since the first publication of this book in 2007! the field of nanoscience and nanomedicine continues to grow substantially. This second edition! Nanotoxicology: Progress toward Nanomedicine! enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints! screening! and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.Topics includeThe impacts of nanotechnology on biomedicine! including functionalization for tissue-specific targeting! the biointeractions of multifunctional nanoparticle-based therapy! and the ability to control specific physicochemical properties of nanoparticles The requirements for proper detection! measurement! and assessment both for workplace exposure and in consumer products-with a focus on potential health and safety implicationsPredictive modeling! using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the bodySpecific methodologies! imaging! and techniques to assess nanomaterials from the manufacturing process to nanomedicine applicationsTools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levelsToxicity of nanomaterials to specific organ systems! cell-based targeting to tumors! and other biomedical applicationsThe difficulty of conducting risk assessments and the need for addressing knowledge gaps! especially with long-term studies A roadmap for future researchThe development of nanotechnology-based products must be complemented with appropriate validated methods to assess! monitor! manage! and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists. Inhaltsverzeichnis Impacts of Nanotechnology on BiomedicineIntroduction to Biomedical Nanotechnology; Dorothy Farrell! George Hinkal! and Piotr GrodzinskiImpact of Bionanointeractions of Engineered Nanoparticles forNanomedicine; Stefania SabellaRational Approach for the Safe Design of Nanomaterials; Anna L. CostaCharacterization of Manufactured Nanomaterials! Dispersion! and Exposure for Toxicological Testing; Keld A. Jensen! Giulio Pojana! and Dagmar BilanicováExposureWorkplace Inhalation Exposure to Engineered Nanomaterials:Detection! Measurement! and Assessment; Araceli Sánchez Jiménez! Derk Brouwer! and Martie Van TongerenNanotechnology in Consumer Products: Addressing PotentialHealth and Safety Implications for Consumers; Treye A. ThomasModelingQuantitative Nanostructure-Activity Relationships: FromUnstructured Data to Predictive Models for DesigningNanomaterials with Controlled Properties; Denis Fourches and Alexander TropshaPharmacokinetics and Biodistribution of Nanomaterials; Jim E. RiviereMethodologies and TechniquesAdvanced Methodologies and Techniques for AssessingNanomaterial Toxicity: From Manufacturing to NanomedicineScreening; Adriele Prina-Mello! Bashir M. Mohamed! Navin K. Verma! Namrata Jain! and Yuri VolkovDetection Methods for the In Vivo Biodistribution of IronOxide and Silica Nanoparticles: Effects of Size! SurfaceChemistry! and Shape; Heather A. Enright and Michael A. MalfattiQuantitative Single-Cell Approaches to Assessing Nanotoxicity inNanomedicine Systems; Ja...

Product details

• Authors: Nancy A. (Kansas State Universit Monteiro-Riviere, Nancy A. (North Carolina State U Monteiro-Riviere, Nancy A. Tran Monteiro-Riviere
• Assisted by: Nancy A Monteiro-Riviere (Editor), Nancy A. Monteiro-Riviere (Editor), Nancy A. (Kansas State University Monteiro-Riviere (Editor), Monteiro-Riviere Nancy A. (Editor), C Lang Tran (Editor), C. Lang Tran (Editor), C. Lang (Institute of Occupational Medicine Tran (Editor), Tran C. Lang (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Paperback / Softback
• Released: 16.11.2016
• EAN: 9781138033993
• ISBN: 978-1-138-03399-3
• No. of pages: 514
• Subjects: Natural sciences, medicine, IT, technology > Physics, astronomy > Atomic physics, nuclear physics; MEDICAL / General, TECHNOLOGY & ENGINEERING / Nanotechnology & MEMS, MEDICAL / Toxicology, biochemistry, Nanotechnology, Materials science, TECHNOLOGY & ENGINEERING / Materials Science / General, Toxicology (non-medical)