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The phenomenon of adhesion is of cardinal importance in the pharmaceutical, biomedical and dental fields. A few eclectic examples will suffice to underscore the importance/relevance of adhesion in these three areas. For example, the adhesion between powdered solids is of crucial importance in tablet manufacture. The interaction between biodevices (e.g., stents, bio-implants) and body environment dictates the performance of such devices, and there is burgeoning research activity in modifying the surfaces of such implements to render them compatible with bodily components. In the field of dentistry, the modern trend is to shift from retaining of restorative materials by mechanical interlocking to adhesive bonding.
This unique book addresses all these three areas in an easily accessible single source. The book contains 15 chapters written by leading experts and is divided into four parts: General Topics; Adhesion in Pharmaceutical Field; Adhesion in Biomedical Field; and Adhesion in Dental Field. The topics covered include:
- Theories or mechanisms of adhesion.
- Wettability of powders.
- Role of surface free energy in tablet strength and powder flow behavior.
- Mucoadhesive polymers for drug delivery systems.
- Transdermal patches.
- Skin adhesion in long-wear cosmetics.
- Factors affecting microbial adhesion.
- Biofouling and ways to mitigate it.
- Adhesion of coatings on surgical tools and bio-implants.
- Adhesion in fabrication of microarrays in clinical diagnostics.
- Antibacterial polymers for dental adhesives and composites.
- Evolution of dental adhesives.
- Testing of dental adhesives joints.
List of contents
Preface xv
Part 1 General Topics
1 Theories and Mechanisms of Adhesion in the Pharmaceutical, Biomedical and Dental Fields 3
Douglas J. Gardner
1.1 Introduction 4
1.2 Mechanisms of Adhesion 7
1.3 Summary 17
References 18
2 Wettability of Powders 23
Emil Chibowski, Lucyna Holysz and Aleksandra Szczes
2.1 Introduction 23
2.2 Different Forms of Wetting 24
2.3 Hydrophilic and Hydrophobic Surfaces 27
2.4 Contact Angle Measurement in Wettability Studies of Powdered Materials 27
2.5 Contact Angle and Surface Free Energy 35
2.6 Surface Free Energy Determination of Powdered Solids by Thin Layer Wicking Method 38
2.7 Surface Free Energy Determination of Powdered Solids by Imbibition Drainage Method 42
2.8 Summary 44
Acknowledgement 44
References 44
Part 2 Adhesion in the Pharmaceutical Field
3 Tablet Tensile Strength: Role of Surface Free Energy 53
Frank M. Etzler and Sorana Pisano
3.1 Introduction 54
3.2 Applicability of the Proposed Model to Pharmaceutical Materials 60
3.3 Discussion 70
3.4 Summary 72
3.5 Acknowledgements 72
References 72
4 Role of Surface Free Energy in Powder Behavior and Tablet Strength 75
Changquan Calvin Sun
4.1 Introduction 75
4.2 Surface Free Energy 76
4.3 Role of Surface Free Energy in Solid Wetting 77
4.4 Role of Surface Free Energy in Powder Flow 80
4.5 Role of Surface Free Energy in Powder Tableting 82
4.6 Concluding Remarks 84
References 84
5 Mucoadhesive Polymers for Drug Delivery Systems 89
Inderbir Singh, Pravin Pawar, Ebunoluwa A. Sanusi and Oluwatoyin A. Odeku
5.1 Introduction 90
5.2 Mucoadhesive Drug Delivery Systems 93
5.3 Mucoadhesive Polymers 95
5.4 Summary 107
References 108
6 Transdermal Patches: An Overview 115
Subham Banerjee
6.1 Introduction 115
6.2 Factors Affecting Skin Absorption 117
6.3 Passive Transdermal Drug Delivery Systems 120
6.4 Types, Structural Components and Materials Used to Design Passive TDDS 121
6.5 Active Transdermal Drug Delivery Systems 126
6.6 Production of Transdermal Patches 127
6.7 Biopharmaceutical Concerns 128
6.8 Pharmacokinetics of Transdermal Absorption 130
6.9 Manufacture, Design and Quality Control 131
6.10 Commercialized Patches 133
6.11 Regulatory Aspects 133
6.12 Summary and Future Prospects 136
Acknowledgment 137
References 138
7 Film-Forming Technology and Skin Adhesion in Long-Wear Cosmetics 141
Hy Si Bui and Debra Coleman-Nally
7.1 Introduction 141
7.2 Long-Wear Foundation: An overview 142
7.3 Effect of Skin Substrate on Adhesion 142
7.4 Long-Wear Technologies in Cosmetic Applications 150
7.5 Summary and Prospects 160
Acknowledgements 161
References 161
Part 3 Adhesion in the Biomedical Fields
8 Factors Affecting Microbial Adhesion 169
Klemen Bohinc, Martina Oder, Rok Fink, Karmen Godiè Torkar, Goran Dra?iæ and Peter Raspor
8.1 Introduction 169
8.2 Surface Characterization 174
8.3 Bacterial Adhesion to Material Surfaces 175
8.5 Summary 179
Acknowledgments 179
References 180
9 Factors Influencing Biofouling and Use of Polymeric Materials to Mitigate It 185
Elena Ozzello, Chiara Mollea, Francesca Bosco and Roberta Bongiovann
About the author
Kashmiri Lal Mittal was employed by the IBM Corporation from 1972 through 1993 Currently, he is teaching and consulting worldwide in the broad areas of adhesion as well as surface cleaning. He is the editor of more than 135 books and the Founding Editor of the journal
Reviews of Adhesion and Adhesives.
Frank Etzler earned his PhD in physical chemistry from the University of Miami. He is currently an Associate Professor of Pharmaceutics in the School of Pharmacy at the Lake Erie College of Osteopathic Medicine (LECOM).
Summary
The phenomenon of adhesion is of cardinal importance in the pharmaceutical, biomedical and dental fields. A few eclectic examples will suffice to underscore the importance/relevance of adhesion in these three areas. For example, the adhesion between powdered solids is of crucial importance in tablet manufacture. The interaction between biodevices (e.g., stents, bio-implants) and body environment dictates the performance of such devices, and there is burgeoning research activity in modifying the surfaces of such implements to render them compatible with bodily components. In the field of dentistry, the modern trend is to shift from retaining of restorative materials by mechanical interlocking to adhesive bonding.
This unique book addresses all these three areas in an easily accessible single source. The book contains 15 chapters written by leading experts and is divided into four parts: General Topics; Adhesion in Pharmaceutical Field; Adhesion in Biomedical Field; and Adhesion in Dental Field. The topics covered include:
- Theories or mechanisms of adhesion.
- Wettability of powders.
- Role of surface free energy in tablet strength and powder flow behavior.
- Mucoadhesive polymers for drug delivery systems.
- Transdermal patches.
- Skin adhesion in long-wear cosmetics.
- Factors affecting microbial adhesion.
- Biofouling and ways to mitigate it.
- Adhesion of coatings on surgical tools and bio-implants.
- Adhesion in fabrication of microarrays in clinical diagnostics.
- Antibacterial polymers for dental adhesives and composites.
- Evolution of dental adhesives.
- Testing of dental adhesives joints.
