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Molecular Biology of Long Non-coding RNAs

English · Paperback / Softback

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Description

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Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

List of contents

Preface.- Chromatin regulation by long non-coding RNAs.- Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs.- Roles of long non-coding RNAs in X-chromosome inactivation.- Roles of Long Non-Coding RNAs in Genomic Imprinting.- Dysregulation of long noncoding RNAs in human disease.- Functions of long non-coding RNAs in non-mammalian systems.- Emerging technologies to study long non-coding RNAs.- Long non coding RNAs and nuclear body formation and function.- Index.

Summary

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Product details

Assisted by Coller (Editor), Coller (Editor), Jeff Coller (Editor), Ahmad Khalil (Editor), Ahmad M. Khalil (Editor), Ahma M Khalil (Editor), Ahmad M Khalil (Editor)
Publisher Springer, Berlin
 
Languages English
Product format Paperback / Softback
Released 01.01.2016
 
EAN 9781493945283
ISBN 978-1-4939-4528-3
No. of pages 227
Dimensions 154 mm x 237 mm x 13 mm
Weight 371 g
Illustrations X, 227 p. 28 illus., 18 illus. in color.
Subjects Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine

B, Medicine, Medical research, Life Sciences, biochemistry, proteins, Human Genetics, Biomedical and Life Sciences, Medical Genetics, Biomedicine, general, Biomedical Research, Protein Science, dysregulation;gene regulation;lncRNAs;long non-coding RNAs

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