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Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions.
Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
List of contents
Preface.- Angiogenesis in diseases and therapy.- Spatiotemporal relation of adipocytes and vascular cells during development.- Adipose stem cells.- Adipose stromal cells.- Vascular adipose complex.- Blood vessels in white and brown adipose tissue.- Lymphatic system in adipose tissues.- The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells.- Vascular and endothelial regeneration.- Angiogenic factors and adipokines in adipose tissue.- Role of NPY in brown adipose tissue and obesity.- Leptin, adiponectin and other angiogenic adipokines in regulation of adipose angiogenesis.- Regulation of adipose angiogenesis by inflammatory cells.- Immune cells in adipose tissue: key players in metabolic.- Adipose tissue hypoxia in regulation of angiogenesis and obesity.- Mouse models to study adipose angiogenesis.- Adipose angiogenesis models in mice and methodology.- Mouse genetic models in studying adipose angiogenesis.- Adipose tissue facilitates tumor angiogenesis and growth.- Adipose tissue-derived progenitor cells and cancer.- Adipose-derived endothelial precursor cells in supporting.- Engineering of vascularized adipose constructs.- Index.
Summary
Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions.
Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
