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Huntington disease is a complex neurodegenerative disorder. Presently, it is being treated sympatomatically based on patient symptoms/ condition. Present work is an attempt of authors to share their observation that treatment with caffeine and dipyridamole displayed significant protection highlighting their neuroprotective efficacy in HD like conditions.This further confirmed that targeting adenosinergic system could be an important therapeutic strategy in the management of HD like symptoms. Further, it has been observed that treatment with rapamycin caused marked improvement in the QA induced behavioural (motor and memory) alteration, oxidative burden, mitochondrial dysfunction, neuroinflammation, apoptosis, neurotrophin levels highlighting role of autophagy in excitotoxic conditions.
About the author
Anil KumarI schloss sein BDS-Studium am IDST Dental College, Kadrabad, abgeschlossen (2019) und mache derzeit meinen MDS in der Abteilung für orale Pathologie und Mikrobiologie am D.J. College, Modinagar, wo ich ein angesehener Pathologe werden möchte."Pathologie ist kein Problem, das gelöst werden muss, sondern die Art und Weise, wie die Seele an sich selbst arbeitet".
