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T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.
List of contents
Key Characteristics of T-type calcium channels (E. Perez-Reyes, author).- Novel T-type calcium channel blockers (M Li, author).- Promotion of cell proliferation by T-type calcium channels (N. Prevarskaya, author).- Role of T-type calcium channels in neuronal differentiation (P. Lory, author).- T-type calcium channel and nociception (H.S. Shin, author).- Activation of endothelial cells by T-type calcium channels (S. Wu, author).- Link between seizures and T-type calcium channels (Y. Chen, author).- Regulation of renal function by T-type calcium channels (P.B. Hansen, author).- Effect of T-type calcium channel activation on smooth muscle cell function (L Cribbs, author).- Does the T-type calcium channel have a function in the heart? (S. Schaffer, author).- Calcium entry via the T-type calcium channel modulates retinal function (E. Carbone, author).- T-type calcium channel and intestines.- Role of T-type calcium channel in bone development (M.C. Farach-Carson, author).- Regulation of pancreatic secretary function by T-type calcium channel (P.O. Berggren, author).- Role of T-type calcium channel in reproduction (T.W. Soong, author)
Summary
T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.
