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The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
List of contents
Part I Targets of Regenerative Medicine for the Inner Ear.- 1 Anatomy of the Inner Ear.- 2 Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear.- 3 Hair cell.- 4 Stereocilia.- 5 Cochlear Lateral Wall.- 6 Spiral Ganglion Cell and Auditory Neuron.- 7 Synaptic Contacts between Hair Cells and Primary Neurons.- 8 Otolith.- 9 Tectorial membrane.- Part II Development of the Inner Ear.- 10 Development and regeneration.- 11 Otic Induction.- 12 Cochlear Development.- 13 Vestibular Development.- Part III Cochlear Implants.- 14 Cochlear Implant: Past, Present and Future.- 15 Recent Progress in Cochlear Implant.- 16 Regenerative medicine in cochlear implantation.- 17 Artificial cochlear epithelium.- 18 Auditory Brainstem Implant.- Part IV Hair Cell Regeneration.- 19 Hair Cell Regeneration in the Avian.- 20 Self Repair.- 21 Transdifferentiation.- 22 Dedifferentiation-mediated Regeneration.- 23 Gene Therapy.- 24 Cell Therapy.- Part V Spiral Ganglion Neuron Regeneration.- 25 Clinical Background.- 26 SGN development.- 27 Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons.- 28 Cell therapy.- 29 Afferent dendrite and axon.- Part VI Stem Cells.- 30 Inner ear stem cells.- 31 Pluripotent Stem Cells.- 32 Somatic Stem Cells.- Part VII Future Perspective.- 33 Regenerative Medicine for the Inner Ear - Summary
About the author
Ito Juichi MD, PhD, Professor and Chairman of Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University.
Summary
The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
Additional text
From the book reviews:
“This is an excellent text concerning differentiation and development of cochlear cells including outer and inner hair cells (OHCs; IHCs). … This is an outstanding book for developmental biologists, audiologists, neurophysiologists, from the beginning to advanced levels. Illustrations and line drawings are in full color and complement the discussion nicely.” (Joseph J. Grenier, Amazon.com, March, 2015)
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From the book reviews:
"This is an excellent text concerning differentiation and development of cochlear cells including outer and inner hair cells (OHCs; IHCs). ... This is an outstanding book for developmental biologists, audiologists, neurophysiologists, from the beginning to advanced levels. Illustrations and line drawings are in full color and complement the discussion nicely." (Joseph J. Grenier, Amazon.com, March, 2015)
