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About 60-70% of diabetics exhibit mild to severe forms of nervous system damage. Understanding the link between type 2 diabetes mellitus and Alzheimer's disease is increasingly important. This study was a trial to focus light on several aspects associated with type 2 diabetes that contribute to Alzheimer's disease and vice versa. In addition, the present study revealed the importance of Abeta40, Abeta42, insulin, HbA1c, lipid profile disturbance, CRP, D-dimer and magnesium in the bidirectional association between type 2 diabetes and Alzheimer's disease pathogenesis which is powered by their association and thus the possibility of depending on the amyloid beta as biochemical marker of type 2 diabetes in Alzheimer's patients was suggested. Also in future, new therapeutic potentials such as neutralization of Abeta by anti-Abeta antibodies could be a new strategy for addressing insulin resistance and diabetes.
About the author
Education: Master degree in Biochemistry, Pharmacy College, Ain Shams University, Cairo, Egypt.Current Job: Research Assistant in Hormone Department, Medical Research Division, National Research Centre, Egypt.
