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Informationen zum Autor Paul A. Bottomley , BSc (Hon.), 1975, PhD, 1978, Physics, University of Nottingham, UK. Research Associate, Johns Hopkins University, Baltimore, 1978-1980. Physicist, G. E. Research and Development Center, 1980-1994. Currently Russell H Morgan Professor and Director of the Division of MR Research, of the Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University. Fellow and Gold Medal recipient of the Society of Magnetic Resonance in Medicine, 1989; Coolidge Fellowship and medal, G.E. Company, 1990; Gold, Silver, and Bronze patent medals, G.E. Company; Gold Medal, American Roentgen Ray Society 2015; over 40 issued patents, about 180 peer-reviewed papers, 24 book chapters, 13 editorials, and over 225 published abstracts. Research specialties: in vivo NMR, MRI, tissue relaxation times, localized NMR spectroscopy, human cardiac NMR spectroscopy, interventional MRI, and MRI safety. John Griffiths, Qualified in medicine and biochemistry. In the early 1980s, his research group pioneered the use of MRS for studies on living tumors, and he has worked since then on MRI and MRS of cancer, both in vivo and ex vivo. He has published more than 300 peer-reviewed articles to date. His recent interests include the metabolomics of cancer. Klappentext This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms-including animal models and patients.Comprised of three parts:* Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring.* Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity.* Reference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae.About eMagRes HandbookseMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.Have the content of this handbook and the complete content of eMagRes at your fingertips!Visit the eMagRes Homepage Zusammenfassung This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms including animal models and patients. Inhaltsverzeichnis 1 Basics of NMR 2 Magnetic Resonance Spectroscopy Instrumentation 3 Detection coils for MRS 4 A Practical Guide to in-vivo MRS 5 Adiabatic Excitation Pulses for MRS 6 Localized MRS employing radiofrequency field (B1) gradients 7 Single Voxel MRS 8 Chemical shift imaging with phase- and sensitivity-encoding <...
List of contents
1 Basics of NMR
2 Magnetic Resonance Spectroscopy Instrumentation
3 Detection coils for MRS
4 A Practical Guide to in-vivo MRS
5 Adiabatic Excitation Pulses for MRS
6 Localized MRS employing radiofrequency field (B1) gradients
7 Single Voxel MRS
8 Chemical shift imaging with phase- and sensitivity-encoding
9 Spatial Encoding and Decoding with Prior Knowledge from MRI and Spatio-Spectral Correlation
10 Accurate Localized Spectroscopy from Anatomically Matched Regions with Optimal Spatial Response Function
11 Accelerated Spatially-Encoded MRS of Arbitrarily-Shaped Compartments Using Linear Algebraic Modeling
12 High-Speed Spatial-Spectral Encoding with Echo-Planar and Spiral Spectroscopic Imaging
13 Direct Water--Fat Imaging Methods: Chemical Shift-Selective and Chemical Shift-Encoded MRI
14 Physiological maintenance in animal experiments
15 Physiological maintenance in MRI and MRS of large animals
16 Physiological Monitoring in human MRS
17 Physiologic Motion: Dealing with Cardiac, Respiratory and Other Sporadic Motion in MRS
18 Quantifying Spectra in the Frequency Domain
19 Quantifying Spectra in the Time Domain
20 Advanced spectral quantification: parameter handling, non-parametric pattern modeling and multi-dimensional fitting
21 1H-NMR Chemical Shifts and Coupling Constants for Brain Metabolites
22 Pattern Recognition Analysis of MR Spectra
23 Quantifying Metabolite Ratios and Concentrations by 1H MRS
24 Quantifying Metabolite Ratios and Concentrations by Non-1H MRS
25 Measuring intra- and extra-cellular pH by MRS
26 Temperature Monitoring Using Chemical Shift
27 Diffusion-Weighted MRS
28 Measuring biochemical reaction rates in vivo with magnetization transfer
29 Proton Chemical Exchange Saturation Transfer MRS and MRI
30 Two-Dimensional NMR Spectroscopy Plus Spatial Encoding
31 Spectral editing
32 Multiple quantum MRS
33 Hyperpolarization Methods for MRS
34 Pulse sequences for hyperpolarized MRS
35 MRS of Perfused Cells, Tissues and Organs
36 Metabolism and Metabolomics by MRS
37 In Vivo 19F MRS
38 13C MRS in Human Tissue
39 Hyperpolarized 13C MRI and MRS Studies
40 Integrating 13C Isotopomer Methods with Hyperpolarization for a Comprehensive Picture of Metabolism
41 Muscle studies by 1H MRS
42 Muscle Studies by 31P MRS
43 Measuring Intracellular Oxygenation with Myoglobin 1H MRS
44 Body Fat MRS
45 In Vivo MRS of Lipids in Adipose Tissue, Bone Marrow, and Liver
46 Assessing Fatty Liver with MRS
47 MRS Studies of Muscle and Heart in Obesity and Diabetes
48 Studying Cardiac Lipids in Obese and Diabetic patients by 1H MRS
49 Cardiac MRS Studies in Rodents and Other Animals
50 Assessing Cardiac Transplant Viability with MRS
51 MRS in the Failing Heart: from Mice to Humans
52 MRS studies of Creatine Kinase metabolism in human heart
53 Studying Aging, Dementia, Trauma, Infection, and Developmental Disorders of the Brain with 1H MRS
54 Studying Stroke and Cerebral Ischemia by 1H MRS
55 31P MRS in Psychiatric Disorders
56 The significance of N-Acetyl Aspartate in Human Brain MRS
57 MRS in Brain Cancer
58 MRS in Breast Cancer
59 MRS in Prostate Cancer
60 Clinical Trials of MRS Methods
61 Clinical Trials that Utilize MRS as a Biomarker
62 Properties of NM
