Pyrazolopyrimidine derivatives as cyclin-dependant kinase inhibitors

This book contains both review and synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as cycline dependent kinase inhibitors (CDKIs). Moreover, cytotoxic activity for the newly synthesized compounds were evaluated, specially on breast cancer cell line (MCF-7). The results obtained were compared with methotrexate as a reference drug. Docking study and molecular modeling were also done using MOE program. I hope this work to be helpful and a starting point for much more new compounds with better activity to help in treatment of such a big terrible disease like cancer. Author: Phoebe F. Lamie

About the author

I'm a Lecturer of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni Suef University,Egypt.I was born in Beni Suef city, Egypt in 1981.I completed my studies as a pharmacist in 2003.I was a demonstrator and then assistant lecturer in the Faculty of Pharmacy, Beni Suef University,Egypt from 2004-2013.Since Feb. 2013,I'm a lecturer.

Product details

• Authors: Phoebe F Lamie, Phoebe F. Lamie, Phoebe F. Lamie
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 01.01.2016
• EAN: 9783659792991
• ISBN: 978-3-659-79299-1
• No. of pages: 248
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry