Signaling by Receptor Tyrosine Kinases

Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth factor. They activate highly conserved intracellular signaling pathways that regulate cell proliferation, differentiation, and metabolism, playing essential roles in developing and adult animals. This book examines the nature of these receptors and their ligands, the molecular mechanisms that they regulate within cells, and the roles of the receptors in normal physiology and control of embryogenesis. It also discusses how dysfunction of these mechanisms can contribute to cancer and other diseases.

Product details

• Authors: Mark A Lemmon, Joseph Schlessinger
• Assisted by: Mark A Lemmon (Editor), Mark A (University of Pennsylvanie School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine) Lemmon (Editor), Mark A. Lemmon (Editor), Joseph Schlessinger (Editor), Joseph (Yale University School of Medicine) Schlessinger (Editor)
• Publisher: Cold Spring Harbor Laboratory Press,U.S.
• Languages: English
• Product format: Hardback
• Released: 31.10.2013
• EAN: 9781936113330
• ISBN: 978-1-936113-33-0
• No. of pages: 478
• Dimensions: 190 mm x 261 mm x 25 mm
• Weight: 1208 g
• Illustrations: Figures; Illustrations, color
• Series: Cold Spring Harbor Perspective; Cold Spring Harbor Perspectives in Biology; Cold Spring Harbor Perspectives in Biology; Cold Spring Harbor Perspective
• Subject: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics