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Informationen zum Autor About the Authors John S. Torday is a Professor of Pediatrics at UCLA, USA. Neil W. Blackstone is a Professor in the Department of Biological Sciences at Northern Illinois University, USA. Virender K. Rehan is a Professor of Pediatrics at UCLA, USA. Klappentext A groundbreaking, evidence-based text to the growing field of evolutionary medicineEvidence-Based Evolutionary Medicine offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine. The text integrates Darwinian principles and evidence-based medicine in order to offer a clear picture of the underlying principles that reflect how and why organisms have evolved on a cellular level.The authors--noted authorities in their respective fields--address evolutionary medicine from a developmental cell-molecular perspective. They explore the first principles of physiology that explain the generation of existing tissues, organs, and organ systems. The text offers an understanding of the overall biology as a vertically integrated whole, from unicellular to multicellular organisms. In addition, it addresses clinical diagnostic and therapeutic approaches, both traditional and cell-homeostatic. This groundbreaking text:* Offers a much-needed, logical, and fundamental approach to biology and medicine* Provides a clear explanation of complex physiology and pathophysiology* Integrates topics like evolution, ecology and aging into mainstream medicine, making them more relevant* Contains the first evidence-based text on evolutionary medicineWritten for medical and graduate students in biology, physiology, anatomy, endocrinology, reproductive biology, medicine, pathology, systems biology, this vital resource offers a unique text of both biology as an integrated whole with universal properties; and of medicine seeing the individual as a whole, not an inventory of parts and diseases. Zusammenfassung "A groundbreaking, evidence-based text to the growing field of evolutionary medicine"--Provided by publisher. Inhaltsverzeichnis Preface xiii 1 A Brief History of Evolutionary Thinking 1 Summary 1 Introduction 2 Darwin 3 Darwin's Theory 6 The Modern Synthesis 7 The Darkest Chapter 9 Conclusions 14 References 14 2 Outlining the Major Transitions in the History of Life 17 Summary 17 Introduction 18 The Major Transitions 20 Conclusions 29 References 30 3 One Central Mystery: Why Did Eukaryotes Only Evolve Once? 31 Summary 31 Introduction 32 Conclusions 45 References 45 4 A Levels¿of¿Selection View of Evolutionary Physiology 49 Summary 49 Conclusions 59 References 59 5 The Cell as the Smallest Functional Unit of Biology/Physiology 63 Summary 63 In the Beginning 64 The Advent of Multicellularity 65 Evolution: Cellular Style 69 The Water-Land Transition and Vertebrate Evolution 70 The Cellular Approach to Evolution Is Predictive 74 We Are Not Just in This Environment, We Are of It 77 Bioethics Based on Evolutionary Ontology and Epistemology, Not Descriptive Phenotypes, and Genes 78 The Theory of Everything (TOE) 79 Coda 81 References 81 6 Development of Tissues and Organs 83 Summary 83 Introduction 83 Lung Alveolar Morphogenesis 85 Parathyroid Hormone¿Related Protein 86 Stretch¿Induced Cell-Cell Interactions 88 References 89 7 When Homeostasis Fails 91 Summary 91 Introduction 91 Peroxisome Proliferator Activated Receptor Gamma as a Connection to the Evolution of the LIF 93 PPAR¿, Statins, and ...
List of contents
We will base the Chapters of the proposed book on EvolutionaryMedicine on standard textbooks of Medicine, physiology andpathophysiology so that the medical student will be able to see howthe evolutionary approach provides a 'logic' for thedescriptive parts lists for health and disease. In examiningHarrison's Principles of Internal Medicine, McCance andHuether's Pathophysiology, and Guyton and Hall'sPhysiology as standard textbooks for medical and graduate schooleducation in biology and medicine, none of them provide anintegrated perspective for the processes of physiology, how theyevolved for homeostasis, how pathophysiology can be viewed as acontinuum from health to disease (and back) as 'failedevolution', regeneration/repair as the recapitulation ofontogeny, and aging as a logical consequence of the evolutionaryphysiologic strategy.
One illustration-related thought would be to have standardschematics for medicine, physiology, and pathophysiology withtransparent overlays of the evolutionary approach so that thestudent can literally 'see' how the descriptive andmechanistic evolutionary approaches are at the same time one andthe same and different.
Working Table of Contents or Outline of contents
1. The Cell as the smallest Unit of Biology/Physiology
2. Development of tissues and organs
3. Mechanisms of Development as the Basis for Homeostasis
4. Cell Communication as the Universal Language of Biology andMedicine
5. Integrated Regulation of Homeostasis- vascular, nervous,endocrine, neuroendocrine, autonomic
6. When Homeostasis Fails
7. Endogenous Mechanisms for Healing
8. Exogenous Mechanisms for Healing- Pharmacologics
9. Exogenous Mechanisms for Healing- Biologics
10. Repair as Ontogeny
11. Regeneration as Phylogeny
12. Systems Biology as Recapitulation of Ontogeny andPhylogeny
13. Bioethics Based on First Principles of Physiology
14. Man's Place in the Universe Redux
