miR-615-5p and miR-155-5p in Hepatocellular Carcinoma Immunotherapy: - A Couple of microRNAs and Four Faces in Natural Killer Cells and Their Target Hepatocytes in HCC

Stemming the rising tide of global ill health from liver disorders, hepatologists worldwide have never been challenged as such. Hepatocellular carcinoma (HCC) poses a heavy burden globally, pivoting on the geographic region, in Egypt; HCC ranks the second most prevalent cancer and the second most frequent cause of cancer related mortality. Yet, compelling the need to understand the pathogenesis of HCC. Despite being considered a main target in efforts directed towards drug development for HCC, the driving motto in the pathogenesis of HCC, IGF/IGF-IR pathway, has recently been cast in the homeostatic regulation of immunity. Provokingly, in my master thesis, I focused on immunotherapy utilizing NK cells to provide new insights in eradicating HCC and reconcile the challenge. Accordingly, miR-615-5p and miR-155 were chosen for such trial, paving the road for correction of NK functional impairment ex-vivo through IGF-axis manipulation and future perfusion of the cytotoxic NKs to HCC patients . Part of this work was presented in the Liver Meeting (AASLD), San Francisco 2015 and in the EASL international liver Congress Vienna 2015 and ranked from the top 10% e-posters in the convention.

Product details

• Authors: A Abdelaziz, Ahmed Ihab Abdelaziz, Mai Ate Rahmoon, Mai Atef Rahmoon, Rana Ahme Youness, Rana Ahmed Youness
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 01.01.2016
• EAN: 9783659823695
• ISBN: 978-3-659-82369-5
• No. of pages: 132
• Subject: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering