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Fungalinfections have taken a new spectrum due to the increased incidence ofmulti-drug resistant fungal pathogens. Freedom of choice for drugs to treatfungal infections is also narrow because of lesser probability of discovering drugsthat would bypass affecting human cells and target fungal cells producing fewerside effects in patients. An approach has gained prominence in research is tolook for bioactive antifungal compounds from natural to synthetic sources. Itis necessary to discover new classes of antifungals to control the recentemergence of multi-drug resistant fungal infections. This book proposed adetails top to bottom outline of antifungal compounds derived naturally orsynthetically. The details of their modifications or synthetic analogues havebeen described, helpful to understand the structure-activity relationship whichleads to new compound development in antifungal chemotherapy. Each chapterbegins with a comprehensive, top-bottom in-depth discussion of antifungalagents with updated bibliographic references. This compendium will serve as acompanion not only for Scientists, Researchers, and Professors, MedicalPractitioners but also a valuable reference text for the university students.
List of contents
1. FungiFights Fungi: Tip off in Antifungal Chemotherapy.- 2. EssentialOil and Antifungal Therapy.- 3. AntifungalPeptides with Potential Against Pathogenic Fungi.- 4. Lipopeptides:Status and Strategies to Control Fungal Infection.- 5. PlantDerived Antifungal Agents: Past and Recent Developments.- 6. RecentAdvancements in Combinational Antifungal Therapy and Immunotherapy.- 7. Nanocarriersof Antifungal Agents.- 8. SyntheticCompounds for Antifungal Chemotherapy.- 9. Antifungaltherapy in Eye infections: New Drugs, New Trends.- 10. AntifungalSusceptibility Testing of Dermatophytes.
About the author
Amit Basak, currently
Professor of Chemistry and Chairman, School of Bioscience, IIT Kharagpur,obtained
his Ph.D. (natural product chemistry) from Calcutta University and D. Phil. (penicillin
biosynthesis) from University of Oxford. He then worked on clavulanic acid
biosynthesis as a postdoctoral fellow at the Johns Hopkins University. His
research interests involve understanding the mechanism of diradical generating
reactions and their applications, development of enzyme inhibitors as
antimicrobial agents and molecular capture chemistry. He has received several
prestigious awards and fellowships for his research contribution.
Ranadhir Chakraborty was born in
Darjeeling. He has worked for Ph.D in the Department of Microbiology, Bose
Institute, Kolkata, India. He is at present serving the Department of
Biotechnology, University of North Bengal, in the capacity of Professor and
Head. He maintained a perfect blend of classical and modern microbiology in his
ongoing journey of Science. He probes some basic scientific problems including
antimicrobial resistance with cutting edge technology of every passing time period.
Santi M. Mandal obtained his Ph D in the field of Molecular
Microbiology and continuing research with major focus in Antimicrobial
Chemotherapy. He visited UTMB-USA and NUS-Singapore for his postdoctoral
training. Recently, he is working as an Assistant Professor of Microbiology at
Vidyasagar University, India. He has published more than 90 research papers in
reputed journals and conferred upon several prestigious awards for his research
contribution.
Summary
Fungal
infections have taken a new spectrum due to the increased incidence of
multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat
fungal infections is also narrow because of lesser probability of discovering drugs
that would bypass affecting human cells and target fungal cells producing fewer
side effects in patients. An approach has gained prominence in research is to
look for bioactive antifungal compounds from natural to synthetic sources. It
is necessary to discover new classes of antifungals to control the recent
emergence of multi-drug resistant fungal infections. This book proposed a
details top to bottom outline of antifungal compounds derived naturally or
synthetically. The details of their modifications or synthetic analogues have
been described, helpful to understand the structure-activity relationship which
leads to new compound development in antifungal chemotherapy. Each chapter
begins with a comprehensive, top-bottom in-depth discussion of antifungal
agents with updated bibliographic references. This compendium will serve as a
companion not only for Scientists, Researchers, and Professors, Medical
Practitioners but also a valuable reference text for the university students.
