Nonmalignant Hematology - Expert Clinical Review: Questions and Answers

This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or "Benign Hematology," with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers willfind that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.

List of contents

Part1. Red Blood Cells.- Evaluation of anemia in children and adults.- Iron cycle and  pathophysiology of iron homeostasis.- Porphyrias: Diagnosis andmanagement.- Disorders of hemoglobin synthesis: Pathophysiology and diagnosticevaluation.- Management of thalassemias.- Allogeneic hematopoietic celltransplant in ß-thalassemia major.- Sickle cell disease: Prevention ofcomplications.- Sickle cell disease: Management of complications.- Allogeneichematopoietic cell transplant in sickle cell disease.- Anemia of inflammation.-Iron overload: Diagnosis, complications and management.- Megaloblastic andnutritional anemias.- Sideroblastic anemias: Diagnosis and management.- Primaryautoimmune warm antibody hemolytic anemias.- Intrinsic hemolytic anemias: Pathophysiology,diagnosis and management.- Part 2. Platelets and Coagulation System.- Plateletdisorders: Diagnostic tests and their interpretations.- Inherited plateletdisorders: Diagnosis and management.- Acquired platelet disorders: Diagnosisand management.- Immune mediated thrombocytopenia.- Coagulation cascade andfibrinolysis pathway: Assessment in the laboratory.- Abnormalities infibrinolysis pathway and clinical implications.- Congenital disorders offibrinogen: Clinical presentations, diagnosis and management.- Hemophilias Aand B: Diagnosis and management.- Coagulation factor inhibitors: Diagnosis andmanagement.- Rare  coagulation factordeficiencies: Diagnosis and management.- von Willebrand disease: Differentialdiagnosis and diagnostic approach to specific subtypes.- von Willebranddisease: Prevention of complications and management of the disease.- Antifibrolytics:Indications and precautions.- Gene therapy for bleeding disorders.- Part 3. Coagulopathyin Systemic Diseases.- Disseminated intravascular coagulopathy.- Coagulopathyin critically ill subjects.- Trauma-associated coagulopathy.- Coagulationrelated issues in malignant hematology: Diagnosis and management.- Unmet clinicalneeds of antithrombotic treatment inBCR/ABL negative myeloproliferative neoplasms.- Bleeding andthrombosis in a cancer patient.- Management of surgical patient with thromboticand bleeding diathesis.- Part 3. Thrombosis and Therapeutics.- Prevention andtreatment of arterial thromboembolism.- mes New Roman","serif"">Prevention of venous thromboembolism.- Diagnostic,prognostic and therapeutic challenges in venous thromboembolisim.- Complicationsof venous thromboembolic disease.- Hereditarythrombophilias: Pathophysiology, timing of testing and familiar testing.- Anti-phospholipidantibodies and syndrome: Complexities in diagnosis and management.- Unidentifiablethrombophilias.- Anticoagulation drugs: Indications, therapeutic monitoring andantidotes.- Heparin induced thrombocytopenia: Diagnosis and management.- Thromboticthrombocytopenic purpura and hemolytic uremic syndrome.- Surgical treatment ofthromboembolic disease.- Part 4. Immune System and Related Disorders.- Nonmalignantleukocyte disorders.- Primary immunodeficiency disorders: Diagnosis andmanagement.- Disorders of phagocytic function:Diagnosis and treatment.- Inherited bone marrow failure syndromes.- Hemophagocytic lymphohistiocytosis: Diagnosisand management challenges.- Lysosomal storage disorders: Hematologyperspective.- Cryoglobulins andcryoglobulinemia.- Part 5. Hemostasis and Thrombosis in Pregnancy, Newbornand Elderly.- Reproductive issues in women with bleeding and thromboticdisorders.- Pregnancy in subjects withhemoglobinopathies: Precautions and management.- Neonatal thrombosis and coagulopathies.-Bleeding and thrombosis in elderly.- Part 6. Transfusion Medicine.- Transfusionsupport: Indications, efficacy and complications.- Human blood antigens andantibodies: Diagnostic and therapeutic implications.- Therapeutic apheresis inhematologic disorders: When and Why?

About the author

Syed
Abutalib is
Assistant Director of Hematology and Blood and Marrow Hematopoietic Cell
Transplant Program. Dr. Abutalib earned his medical degree from Dow Medical
College in Karachi, Pakistan and subsequently completed a residency in Internal
Medicine at Cook County Hospital and a Fellowship in Hematology/Oncology at the
University of Illinois at Chicago. During his Fellowship he participated in
Leukemia Research at Northwestern Hospital & University of Chicago. Board
certified in Internal Medicine, Medical Oncology and Hematology, Dr. Abutalib
specializes in benign hematology, malignant hematology and hematopoietic blood
and marrow cell transplant. Dr. Abutalib has been published in several
peer-reviewed journals, including the American Journal of Hematology, Current
Pharmaceutical Biotechnology, and the American Journal of
Clinical Pathology and has written chapters for medical
textbooks, including Acute Leukemias (2008), Evidence-Based
Hematology(2008), Expert Hematology & Oncology Essentials (2014)
and Cancer Consult-Expertise for Clinical Practice (2014),
Essential Oncology (2015). Dr. Abutalib is the editor of several books
including, Cancer Consult-Expertise for Clinical Practice published
on behalf of Blackwell Wiley Health Sciences. He is on the editorial board
for Clinical Oncology News and THE ASCO POST magazine
and contributes regularly in the column " How
I Manage.." and “Expert Hematology Review”,
respectively. Besides his Patients he hold Medical Education dear to his
heart. 
Jean M. Connors is an Assistant Professor of
Medicine at Harvard Medical School. Dr Connors received her medical degree from
Johns Hopkins University School of Medicine in Baltimore, Maryland. She
completed residency in Internal Medicineat Beth Israel Hospital, Boston,
Massachusetts, and fellowships in both Hematology/Oncology and Transfusion
Medicine at Brigham and Women’s Hospital, Boston. Dr Connors cares for patients
with inherited and acquired thrombotic and coagulation disorders. As
Medical Director of the Brigham and Women’s Hospital and Dana Farber Cancer
Institute Anticoagulation Management Service, Dr Connors oversees
anticoagulation practices in outpatient clinical settings. She is also the
Medical Director of the Hemostatic Antithrombotic Stewardship program, a
multi-disciplinary care delivery program, to ensure judicious and optimal use
of anticoagulants and clotting factors across all BWH inpatient services. She
has participated in a variety of types of clinical trials focusing
on anticoagulation including investigator initiated, served on scientific
advisory boards for a number of companies, teaches extensively at many levels
including peers in CME courses as well as fellows and residents, and has
written numerous reviews and chapters in the area of thrombosis-hemostasis.
Margaret
Ragni is a
Professor of Medicine and Clinical Translational Science at the University
of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. She received her MD
from the University of Pittsburgh School of Medicine and a Master of Public
Health from the University of Pittsburgh School of Public Health. She completed
her residency and fellowship in hematology/oncology at the University of
Pittsburgh Medical Center in Pittsburgh, where she joined the faculty in 1983.
Dr. Ragni’s research interests are in congenital and acquired disorders of
hemostasis and thrombosis, and, in, particular in novel therapeutics for
patients with hemophilia with and without inhibitors. She serves on the Medical
and Scientific Advisory Committee of the National Hemophilia Foundation (NHF),
the FDA Blood Products Advisory Committee, the Scientific Committee on
Hemostasis of the American Society of Hematology,and on the Medical Advisory
Board for the Foundation for Women and Girls with Blood Disorders (FWGBD). She
also served as Co-Chair for the 2014 ASH Annual Meeting; as Co-Chair of the
Research Committee of the Hemostasis & Thrombosis Research Society, and is
a member of the Research Committee of the American Thrombosis & Hemostasis
Network. She is past member of the Hemostasis Thrombosis Study Section of the
NHLBI, and Co-Chair of the Bleeding Disorders Subcommittee of the NHLBI State
of the Science Symposium. She serves on Scientific Advisory Boards for Alnylam,
Baxalta, Biogen, and Biomarin. She has conducted numerous clinical
trials, observational studies, retrospective data base analyses,
cost-effectiveness analyses, and investigator-initiated new drug trials in
hemophilia and von Willebrand disease. She is the medical director of the
Hemophilia Center of Western PA, providing care for patients with bleeding and
clotting disorders, teach and mentor medical students, residents, fellows, and
young faculty.

 

Summary

This book, in Q&A format, addresses a wide range of clinically relevant
topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a
view to offering a robust, engaging tool that will assist every hematologist and
oncologist (pediatric and adult equally) in making decisions during day-to-day
practice. The entire spectrum of the specialty is covered in more than 60
exceptional chapters written by acknowledged authorities in the field. The
content is organized into well-designed broad sections on red cell disorders,
platelet and coagulation disorders, coagulopathy in systemic diseases,
thromboembolic disease and its management (including surgical), immune system
and related disorders, hemostasis and thrombosis during pregnancy and in the
newborn and elderly, and Transfusion Medicine. A key aspect of the book is the
opportunity it affords expert physicians to express well-reasoned opinions
regarding complex issues in Nonmalignant Hematology. Readers willfind that it
provides a practical and immediately applicable compendium of answers to often
complex and vexing questions. It will appeal to residents, fellows, house
officers and more experienced practitioners around the globe.

Product details

• Assisted by: Syed A. Abutalib (Editor), Jean M. Connors (Editor), Jea M Connors (Editor), Jean M Connors (Editor), Margaret V. Ragni (Editor), Margaret V Ragni (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2016
• EAN: 9783319303505
• ISBN: 978-3-31-930350-5
• No. of pages: 718
• Dimensions: 182 mm x 262 mm x 39 mm
• Weight: 1672 g
• Illustrations: XVI, 718 p. 76 illus., 59 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Krankenpflege, Onkologie, B, Pädiatrie, Medicine, Pediatrics, Nursing, INTERNAL MEDICINE, Hematology, Oncology, Paediatric medicine