Mitochondrial Dysfunction in Neurodegenerative Disorders

This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson's disease, Alzheimer's disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets. 
Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins. 

Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.

List of contents

Part I.Mitochondria and Neurodegenerative Disease.- An Introductionto Mitochondria, Their Structure and Functions.- Part II.Mitochondrial Dysfunction: Causes and Effects?.- Neurodegeneration in Mitochondrial Disorders.- The Ageing Brain,Mitochondria and Neurodegeneration.- Mitochondrial Genes and Neurodegenerative Disease.- MitochondrialSignalling and Neurodegeneration.- Part III. Functional Consequences ofMitochondrial Dysfunction.- Life on the Edge: Determinants of SelectiveNeuronal Vulnerability in Parkinson's Disease.- MitochondrialDynamics and Neurodegeneration.- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation.-Mitochondria,the Synapse, and Neurodegeneration.- Protein Misfolding andAggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration.-Mitochondrial Degradation, Autophagy andNeurodegenerative Disease.- The DeleteriousDuo of Neurodegeneration: Lysosomes and Mitochondria.- PartIV. Measuring theContribution of Mitochondrial Dysfunction to Neurodegenerative Disease.- CanWe Accurately Model Mitochondrial Dysfunction in Neurodegeneration?.- MitochondrialFunction and Dynamics Imaged In Vivo.-Part V.  The Future.- Developmentof Treatments and Therapies to Target Mitochondrial Dysfunction.- Summary and Conclusions.

About the author

Amy K. Reeve
Amy did her undergraduate degree
in Neuroscience at Edinburgh University before moving to the Mitochondrial
Research Group at Newcastle University for her PhD studies. She completed her PhD
in the study of the molecular mechanisms of neurodegenerative disease in 2007
and now has her own research group within the Wellcome Trust Centre for
Mitochondrial Research. Her current research interests centre around
understanding the mechanisms behind the neurodegeneration seen in Parkinson’s
disease, and the contribution of mitochondrial dysfunction to these changes.
Funded by Parkinson’s UK as a research fellow Amy’s interests lie in
understanding how changes within mitochondria, mitochondrial transport and the
interaction of mitochondrial with alpha-synuclein contributes to the
development of Parkinson’s disease.
Eve M. Simcox
Eve did her undergraduate degree
in Biomedical Science at Newcastle University and continued her studies within
the Mitochondrial Research Group for her PhD. She completed her PhD in the
study of the turnover and dynamics of mitochondria in neurodegenerative disease
in 2014 and now works as the impact officer for the faculty of Science,
Agriculture and Engineering.
Michael R. Duchen
Michael obtained his Bachelor of Medicine degree from Oxford
and London Universities, and moved to UCL for his PhD studies. He has remained
at UCL since, where he is now a Professor of Physiology. Michael founded and
leads the UCL consortium for Mitochondrial Research and leads a successful
research group. Michael's interests lie primarily in understanding the relationships
between mitochondrial biology and cell signalling. His research group's main
interest lies in understanding the inter-relationship between calcium
signalling, mitochondria and free radical biology in cell physiology and
pathophysiology. Particular contributions have been made into understanding the
contribution of mitochondrial dysfunction to cell injury and death.

Doug M. Turnbull
Professor Turnbull is a clinical academic who leads a basic
science research programme in conjunction with developing clinical services. He
has three main roles.
Director of the Wellcome Trust Centre for Mitochondrial
Research. The Wellcome Trust Centre is focused on research to improve the lives
of patients with mitochondrial disease. This includes research to identify the
genetic defect in patients with mitochondrial disease and his work also focuses
understanding the molecular mechanisms underlying the neurological features in
patients. With colleagues he is searching for new therapies for patients and actively
involved in clinical studies evaluating potential therapies. He has been
actively involved in work to prevent the transmission of mitochondrial DNA
disease using an IVF technique called mitochondrial donation.

Lead for the NHS Highly Specialised Services for Rare
Mitochondrial Services for Adults and Children. Professor Turnbull developed
this service provides optimum care for patients with mitochondrial disease
throughout the UK with Centres in Newcastle, London and Oxford. This service
was built on the back of clinical and basic research and the service reviews in
excess of 800 patients per year. The service has developed care pathways and
patient guidance that are used worldwide of the benefit of patients.

Director MRC/BBSRC Centre for Ageing and Vitality. Professor
Turnbull has a major interest in understanding the basic mechanisms involved in
human ageing with particular emphasis on the role of mitochondria. The MRC
Centre is focused on understanding how these mechanisms are influenced by
lifestyle interventions and studies aimed at promoting healthy ageing.

Summary

This second edition brings together up-to-date contributions
from leaders in the field internationally on the various ways in which
mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative
diseases, including Parkinson’s disease, Alzheimer’s disease and multiple
sclerosis. The reader is guided through the basic functions of mitochondria and
the mechanisms that lead to their dysfunction, and on to the consequences of
this dysfunction for neuronal function before finishing with the modelling of
these disorders and discussion of new potential therapeutic targets. 
Additional chapters have been added to the book to reflect
advances in the field and there are many new contributors and topics, including
how mitochondria are degraded and the interaction of the mitochondria with
pathologically relevant proteins. 

Mitochondrial Dysfunction in Neurodegenerative Disorders
provides an accessible, authoritative guide to this important area for
neurologists; research and clinical neuroscientists; neuropathologists; and
residents with an interest in clinical research.

Product details

• Assisted by: Michael R. Duchen (Editor), Ev M Simcox (Editor), Eve M Simcox (Editor), Michael R Duchen et al (Editor), Amy K. Reeve (Editor), Amy Katherine Reeve (Editor), Eve Simcox (Editor), Eve M. Simcox (Editor), Doug M. Turnbull (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2016
• EAN: 9783319286358
• ISBN: 978-3-31-928635-8
• No. of pages: 380
• Dimensions: 161 mm x 241 mm x 20 mm
• Weight: 767 g
• Illustrations: XI, 380 p. 34 illus., 29 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; B, Medicine, Neurology, INTERNAL MEDICINE, Neuroscience, biochemistry, Neurosciences, Clinical & internal medicine, Medical Biochemistry