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This bookdescribes the diverse roles that growth factors and cytokines play in skeletalmuscle. The extracellular environment has profound effects on the biology ofskeletal muscle. The soluble portion of this environment includes a rich milieuof growth factors and cytokines which have been shown to regulate virtually allfacets of the response of skeletal muscle to external stimuli, whether it beexercise induced metabolic shifts, remodeling in response to trauma or loadingof the ongoing pathology associated with neuromuscular disease.
Thechapters included in this work illustrate growth factors that directly affectskeletal muscle cells and those which influence non-muscle cells thatcontribute to the biology of skeletal muscle as a whole tissue. The currentstate of the art, with the advent of systems biology, allows for thedelineation of signaling networks which are regulated by suites of growthfactors. This is in stark contrast to early more traditional studies, whichonly examined the effects of isolated growth factors on the activity ofskeletal muscle precursor cells in tissue culture.
The workpresented in this volume ranges from reviewing and analyzing the roles ofindividual growth factors in detail, to the complex interplay of multiplesoluble factors in the control of muscle functional, and dysfunctional states.The material covered in this volume will particularly suit readers from a rangeof research fields spanning general muscle biology and physiology, and thoseworking on diseases and conditions affecting skeletal muscle both directly andindirectly.
List of contents
Hepatocyte Growth Factorand Satellite Cell Activation.- Cytokine mediatedcontrol of muscle stem cell function.- Therole of Leukemia inhibitory factor receptor signaling in skeletal musclegrowth, injury and disease.- Function ofMembrane-Associated Proteoglycans in the Regulation of Satellite Cell Growth.- The TGF-beta signalling network in muscle development,adaptation and disease.- Adipokines in healthy skeletal muscle andmetabolic disease.- Role of growth factors in modulation of the microvasculaturein adult skeletal muscle.
Summary
This book
describes the diverse roles that growth factors and cytokines play in skeletal
muscle. The extracellular environment has profound effects on the biology of
skeletal muscle. The soluble portion of this environment includes a rich milieu
of growth factors and cytokines which have been shown to regulate virtually all
facets of the response of skeletal muscle to external stimuli, whether it be
exercise induced metabolic shifts, remodeling in response to trauma or loading
of the ongoing pathology associated with neuromuscular disease.
The
chapters included in this work illustrate growth factors that directly affect
skeletal muscle cells and those which influence non-muscle cells that
contribute to the biology of skeletal muscle as a whole tissue. The current
state of the art, with the advent of systems biology, allows for the
delineation of signaling networks which are regulated by suites of growth
factors. This is in stark contrast to early more traditional studies, which
only examined the effects of isolated growth factors on the activity of
skeletal muscle precursor cells in tissue culture.
The work
presented in this volume ranges from reviewing and analyzing the roles of
individual growth factors in detail, to the complex interplay of multiple
soluble factors in the control of muscle functional, and dysfunctional states.
The material covered in this volume will particularly suit readers from a range
of research fields spanning general muscle biology and physiology, and those
working on diseases and conditions affecting skeletal muscle both directly and
indirectly.
