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This comprehensive and authoritative book discusses the critical role of the utero-placenta in neurodisability, both at term and preterm. It examines aspects of fetal compromise and possible cerebro-protective interventions, recent evidence on fetal growth and mental illness, as well as cerebro-therapeutics. Throughout the book, information from the basic sciences placed within the clinical context.
- Written by leading obstetricians, neonatologists, paediatricians and pathologists.
- Discusses the role of placenta in the pathophysiology of CNS
- Examines recent evidence of endocrine, haematological and inflammatory origins of utero-placental dysfunction
- Reviews latest advances in antepartum and perinatal imaging
List of contents
1. Placental pathology and perinatal brain injury
Raymond Redline 2. Abnormal Placental Phenotypes
Colin Sibley and Michelle Desforges 3. Aberrant placental endocrinology, fetal growth and neurodevelopment
Jayne Charnoc and Melissa Westwood 4. The rheology of utero-placental and feto-placental blood flow
Ian Crocker 5. Inflammation and Placentation
Karen Racicot and Gil Mor 6. Infections and the fetal inflammatory response
Donald Peebles and Catherine James 7. Cerebral ischaemia and white matter injury
Suresh Victor and Michael Weindling 8. In utero imaging of the human placenta
Emma Ingram and Ed Johnstone 9. Cerebral Function and Fetal Growth Restriction
Irene Cetin and Valentina Brusati 10. Placental programming and mental illness: fetal growth and schizophrenia
Kathryn Abel and Martin Allin 11. Cerebro-therapeutics
Philip Steer 12. Summing up and unsolved problems
Karin Nelson
About the author
Dr Ian Crocker is a senior scientist within the Maternal and Fetal Health Research Centre in Manchester, UK. He is an NIHR Fellow, with a 10-year research focus on the human placenta. He is a member of the Maternal Medicine Clinical Studies Group, part of the Comprehensive Clinical Research Network, treasurer of the Blair Bell Society, the research arm of the Royal College of Obstetricians and Gynaecologists, editorial board member of the journal
Placenta, and 2006 recipient of the prestigious Gabor Than Award from the International Federation of Placental Associations, for his outstanding contributions to placental research.
Dr Martin Bax worked in community paediatrics for 40 years. He is Emeritus Reader in Child Health at Imperial College London and Honorary Consultant Paediatrician at the Chelsea and Westminster Hospital campus. Dr Bax was for many years the senior editor of Developmental Medicine and Child Neurology. He co-edited the third edition of Aicardi's
Diseases of the Nervous System in Childhood. Until recently he was the Scientific Director of the Castang Foundation, a charity dedicated to investigating the causes and prevention of childhood neurodisability. He is president of the Society for the Study of Behavioural Phenotypes.
Summary
This comprehensive and authoritative book discusses the critical role of the utero-placenta in neurodisability, both at term and preterm. It examines aspects of fetal compromise and possible cerebro-protective interventions, recent evidence on fetal growth and mental illness, as well as cerebro-therapeutics.
