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Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.
List of contents
Redox Regulation of PTPs in Metabolism: Focus on Assays.- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling.- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism.- PTP1B and TCPTP in CNS Signaling and Energy Balance.- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress.- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling.- PTP1B in Obesity-Related Cardiovascular Runction.- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism.- Metabolic Effects of Neural and Pancreatic SHP2.- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism.- The Role of LMPTP in the Metabolic Syndrome.- Mitogen-Activated Protein Kinase Phosphatases in Metabolism.- Glycogen Metabolism and Lafora Disease.- Index.
Summary
Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.
