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Micro-bubbles filled with gas and surrounded by a thin elastic shell are used as contrast agents in medical imaging with ultrasound. The interest in using the micro-bubbles for blood pressure measurements in the left ventricle of the heart and other organs has been raised in the last years. This task requires better understanding of the micro-bubbles properties driven by acoustic force and the conditions for creation of non-linear effects such as appearance of half-harmonic component in the signal radiated from the micro-bubbles. This work uses laboratory experiments in order to investigate the conditions for creation of half-harmonic component. The experiments are designed to better understand the micro-bubble properties and to explore the possible methods for future applications of micro-bubbles for blood pressure measurements. The response of the micro-bubbles to the driving ultrasound force is defined by their physical properties: micro-bubbles resonance frequency , the distribution of the micro-bubbles population radii and gas diffusion process.The micro-bubbles respond in a non-linear manner to the acoustic pressure above specific threshold.
About the author
Alexander Rosen received M.Sc degree at the Faculty of Biomedical Engineering, Technion, Haifa, Israel. His work was in the field of ultrasound imaging and pressure measurements using contrast agents. His present areas of research are signal processing algorithms in the area of optical communication and time interleaved data converters.
