Polymorphisms in some genes associated with type 1 diabetes mellitus

Type 1 diabetes (T1DM) is an autoimmune disease characterized by immune destruction of insulin-producing pancreatic beta cells. This leads to dysfunctional regulation of blood glucose levels in T1DM patients. The destruction of beta -cells of Langerhans islets is caused by infiltration of dendritic cells, macrophages and T lymphocytes. Normally, genetic susceptibility (association) studies depend on assessing the role of genotype markers (typically SNPs) in the susceptibility to the disease of interest in a case- control or family based sample. Many genes associated with type 1 diabetes mellitus, CTLA-4, PTPN22, IL-10, IL-18, VIT-D receptor are one of the common confirmed T1DM susceptibility genes

About the author

Ali Salim Al-Shehmany, M.Sc. Biotechnology-Clinical Molecular Genetics, Assist. Lecturer in Branch of Basic Science, College of Dentistry, University of Wasit

Product details

• Authors: Ali Salim Al-Shehmany
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 31.08.2015
• EAN: 9783659756375
• ISBN: 978-3-659-75637-5
• No. of pages: 72
• Subject: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering