Metal-Carbon Bonds in Enzymes and Cofactors

The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.

List of contents

From the Content:
- Organometallic Chemistry of B12 Coenzymes
- Cobalamin- and Corrinoid-Dependent Enzymes
- Nickel-Alkyl Bond Formation in the Active Site of Methyl-Coenzyme M Reductase
- Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases
- Structure and Function of [NiFe]-Hydrogenases
- Carbon Monoxide and Cyanide Ligands in the Active Site of [FeFe]-Hydrogenases
- Carbon Monoxide as Intrinsic Ligand to Iron in the Active Site of [Fe]-Hydrogenase
- The Dual Role of Heme as Cofactor and Substrate in the Biosynthesis of Carbon Monoxide
- Copper-Carbon Bonds in Mechanistic and Structural Probing of Proteins as well as in Situations where Copper Is a Catalytic or Receptor Site
- Interaction of Cyanide with Enzymes Containing Vanadium, Manganese, Non-Heme Iron, and Zinc
- The Reaction Mechanism of the Molybdenum Hydroxylase Xanthine Oxidoreductase: Evidence Against the Formation of Intermediates Having Metal-Carbon Bonds
- Computational Studies of Biooganometalllic Enzymes and Cofactors

About the author

Helmut und Astrid Sigel, University of Basel, Switzerland. Roland K. O. Sigel, University of Zürich, Switzerland.

Product details

• Assisted by: Roland K O Sigel (Editor), Astrid Sigel (Editor), Helmu Sigel (Editor), Helmut Sigel (Editor), Roland K. O. Sigel (Editor), Roland K.O. Sigel (Editor)
• Publisher: De Gruyter
• Languages: English
• Product format: Hardback
• Released: 30.06.2015
• EAN: 9783110442793
• ISBN: 978-3-11-044279-3
• No. of pages: 510
• Dimensions: 156 mm x 36 mm x 234 mm
• Weight: 938 g
• Illustrations: 50 b/w and 30 col. ill., 50 b/w tbl.
• Series: Metal Ions in Life Sciences; Metal Ions in Life Sciences; ISSN
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Non-fiction book > Nature, technology > Natural science