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In collaboration with physicist and mathematician Hans Carlos Hofmann he developed the hard-software combination CATEEM® in 1989, which allows cartography of electric changes of the human brain in real time, not only for diagnostic purposes but also for therapy control in medicine and psychology. Recently, the technology has also been introduced into market research under the topic of "Neuromarketing", where a combination of these brain maps "(enkephaloglyphs" obtained by Neurocode-Tracking) together with Eye-Tracking opens a new dimension of brain research. More than 100 publications proof the benefit of the technology in research and practice.The current book provides a representative overview on the use of neurophysiological methods during drug discovery aiming also at the need of saving animals. The holistic approach describes the feasibility of this goal and emphasizes the possibility to carry over parameters of drug effectiveness in rats to testing in humans. The use of identical parameters of drug induced changes of electric activity in rats and humans documents a very good example of translational medicine, which is not reached easily by use of any other method. In addition, large databases in rats and humans meanwhile allow yet unknown classifications of herbal medicines as well as elucidation of their mechanisms of action.
About the author
Wifried Dimpfel, born 1945 in Königswinter, Germany, studied veterinary medicine in Berlin and Munich. In 1973 he finished his inaugural dissertation at Free University Berlin. In 1976 he got his habilitation (pharmacology and toxicology) at the department of human medicine at Justus-Liebig-University of Giessen, Germany, governed by Prof. Dr. Ernst Habermann. Since 1983 he is Honorary Professor at the Rudolf Buchheim Institute for Pharmacology, University of Giessen. For many years he acted as chief editor of the "European Journal of Medical Research". As "Max Kade scholar, New York" he joined the National Institute of Health in Bethesda discovering his fascination for electric events produced by the nervous system. His view to analyze drug effects using neurophysiological methods in a more effective manner in comparison to other methods has been confirmed since then. Together with biologist Dr. Manfred Spüler he developed preclinical approaches succeeding in entirely new characterizations of drug effects based on the changes of electric activity of rat brain in vitro and in vivo.
