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Informationen zum Autor Simon Shorvon MA MB BChir MD FRCP Professor in Clinical Neurology and Clinical SubDean, UCL Institute of Neurology, University College London and Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK Emilio Perucca MD PhD FRCP(Edin) Professor of Medical Pharmacology, Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; and Director, Clinical Trial Center, C Mondino National Neurological Institute, Pavia, Italy Jerome Engel Jr MD PhD Director, Seizure Disorder Center, Jonathan Sinay Distinguished Professor, Neurology, Neurobiology, Psychiatry and Behavioural Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Klappentext The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy.* The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated* The first two sections cover the background to, and principles of, treatment in different clinical situations* Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects* Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach* This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries Zusammenfassung The Treatment of Epilepsy! fourth edition! is a comprehensive reference and clinical guide to the pharmacological! medical and surgical options available in the treatment of epilepsy.* The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated* The first two sections cover the background to! and principles of! treatment in different clinical situations* Section three comprises a series of systematic reviews of contemporary drug therapy! devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects* Section four focuses on the surgical options! devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach* This 4th edition is extensively revised incorporating the many recent developments in therapy! and comprises 81 chapters from world experts from 18 countries Inhaltsverzeichnis List of Contributors Preface to the Fourth Edition Preface to the First Edition Historical Introduction: The Drug Treatment of Epilepsy from 1857 to 2015 Simon Shorvon Section I ? Introduction (Lead editor: Simon Shorvon) 1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE 1 Simon Shorvon 2 Differential Diagnosis of Epilepsy 24 Mark Cook 3 Mechanisms of Epileptogenesis 38 Giuliano Avanzini and Silvana Franceschetti 4 Antiepileptic Drug Discovery 52 H. Steve White and Melissa Barker-Haliski 5 Antiepileptic Drug Development 61 Dieter Schmidt 6 Mechanisms of Antiepileptic Drug Action 75 Matthew C. Walker and Rainer Surges 7 Mechanisms of Drug Resistance and Tolerance 92 Wolfgang Löscher and Dieter Schmidt 8 Epilepsy Biomarkers 103 Jerome Engel, Jr. and Asla Pitkänen Section II ? Principles of Medical Management (Lead editor: Simon Shorvon) 9 General Principles of Medic...
