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A closer look at naturally occurring polyyne compounds reveals some fascinating elements of molecular architecture. These structurally unique classes of compounds, as well as a host of analogs, exhibit a variety of biological effects, including antimicrobial, anti-inflammatory, antitumor, antiangiogenic and anti-HIV activities. The distinct biological activities of these molecules have motivated synthetic organic chemists worldwide to plane and execute their total syntheses. Most natural polyynes pose a substantial synthetic challenge because of their highly unsaturated nature. This book recounts these synthetic achievements and also highlights both the natural source(s) and biological relevance for many of these compounds.
About the author
Dr. Bishwajit Saikia earned his Ph.D. in Organic Chemistry from Natural Products Chemistry Division, CSIR-NEIST, Jorhat, Assam, under Dibrugarh University, Assam, INDIA. He is currently working as an Assistant Professor, Department of Chemistry, Dibrugarh University, Assam. His research interests in total synthesis of bioactive natural products.
