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This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles - a research goal that is currently being pursued by several groups around the globe.
List of contents
Introduction.- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation.- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation.- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles.- Hyp-Polydendrons; studies of nanoprecipitation behavior.- Conclusions and Future work.- Experimental.
About the author
Dr. Fiona L. Hatton obtained a 1st class MChem degree in medicinal chemistry and pharmacology from the University of Liverpool, UK, 2010. She received her PhD in 2014 from the same university, under the supervision of Prof. Steve Rannard, specializing in polymer chemistry, more specifically hyperbranched polydendrons. Fiona joined the division of Coating Technology, KTH Royal Institute of Technology, Sweden in 2014 as a postdoctoral researcher working for associate professor Anna Carlmark.
Summary
This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.
