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The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.
This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
List of contents
Preface.- Stress-induced mutagenesis in bacteria.- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress.- Transcription-mediated mutagenic processes.- Transposon mutagenesis in disease, drug discovery and bacterial evolution.- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution.- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors.- Microsatellite Repeats: Canaries in the Coalmine.- Genetic instability Induced by hypoxic stress.- Radiation-induced delayed genome Instability and hypermutation in mammalian cells.- Radiation-induced bystander effects and stress-induced mutagenesis.- Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis.- The transgenerational effects of parental exposure to mutagens in mammals.- Revisiting mutagenesis in the age of high-throughput sequencing.- Index.
Summary
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.
This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
