A Novel Enantioselective Synthesis of Spiro-Oxindoles - Analogs of Horsifiline and Spirotryprostatin

Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow preparation of a library of compounds for biological screening.

About the author

Sesha Sridevi Alluri- A Doctoral student, working with Prof. A. K. Ganguly at stevens Institute of Technology, NJ, USA. She is a co-inventor on two patents and a recipient of several awards and fellowships.

Product details

• Authors: Sesha Sridev Alluri, Sesha Sridevi Alluri, Mi Bertucci, Michael Bertucci, Chih-Hun Wang, Chih-Hung Wang
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 01.01.2010
• EAN: 9783838355085
• ISBN: 978-3-8383-5508-5
• No. of pages: 76
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry