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Klappentext Nanomedicine is a rapidly developing field with new techniques and applications under constant development. This book provides an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine. Chapters written by experts in the field address promises, prospects, and pitfalls of nanopharmacology illustrated with case studies on nanomedicines in, or about to enter, human clinical trials. Methods for drug deployment and targeting, barrier penetration, imaging and theranostics development are covered in detail. Readers will find answers to formulation, safety and regulatory considerations as well as a current representation of nanotechnology from a drug development perspective. Covering a wide range of areas in detail, this book will provide an excellent companion for medicinal chemists, pharmacologists and biochemists working in industry or academia. Zusammenfassung This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine. Inhaltsverzeichnis Design Considerations for Properties of Nanocarriers on the Disposition and Efficiency of Drug and Gene Delivery; Targeting Cyclins and Cyclin-Dependent Kinases Involved in Cell Cycle Regulation by RNAi as a Potential Cancer Therapy; Nanoparticle carriers to overcome biological barriers to siRNA delivery; Magnetic targeting as a vehicle for delivery of nanomedicines; Development of Theranostics - Imaging Considerations and Targeted Drug Delivery; The Role of Imaging in Nanomedicine Development and Clinical Translation; Anticancer agent-incorporating polymeric micelles: from bench to bedside; Polymeric Nanoparticles and Cancer: Lessons Learnt from CRLX101; Nanodelivery Strategies in Breast Cancer Chemotherapy; Developing a Predictable Regulatory Path for Nanomedicines by Accurate and Objective Particle Measurement; Nanomedicine: Promises and Challenges; The Challenge of Regulating Nanomedicine: Key Issues; Doxil® - The First FDA-Approved Nano-Drug: From Basics via CMC, Cell Culture and Animal Studies to Clinical Use...
