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High-pressure liquid chromatography (HPLC) used in the analytical development to quantify the biological sample concentration, the active pharmaceutical ingredient (API) and to evaluate the impurity and degradation product profiles of the drug substances (DS) and drug products (DP). Additional uses of HPLC include determination of content uniformity of dosage form, monitoring of dissolution profiles, determination of antioxidants and preservative content and supporting of cleaning validations. UV spectroscopy is one of the most frequent used techniques in pharmaceutical analysis. It involves the measurement of UV radiation absorbed by a substance in solution. The wavelength range of UV radiation is 200-400nm (180-380 nm) and the UV radiation has a sufficient energy to excite valance electrons in many atoms or molecules; consequently, UV is involved with electronic excitation.
About the author
Md.Mazharul Islam Chowdhury obtained his B.Pharm (Hons.) and M.Pharm degrees from the University of Dhaka in 2006 and 2007 respectively. Later on Mr. Chowdhury joined to Novartis Bangladesh Ltd. in the Department of Product Development as a Formulation Research Officer and then joined at ASA University Bangladesh as a Lecturer
