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With its list of contributors reading like a who's who, this is the ultimate standard reference on phosphorus in catalysis. Clearly divided into substance classes and spanning three volumes, it provides readers with an excellent introduction to the multitude of applications, backed by examples of optimal solutions. A definite must-have for all chemists working in synthetic chemistry, ranging from natural product synthesis to the production of pharmaceuticals.
List of contents
IntroductionTRIVALENT PHOSPHOROUS LIGANDS IN METAL-CATALYZED REACTIONSChiral Monodentate Phosphorous LigandsChiral Bidentate Phosphorous LigandsChiral Polyphosphorous LigandsDYNAMIC PROCESSES OF P-LIGAND COMPLEXESChiral Secondary Phosphine Oxides and Heteroatom-Substituted Secondary Phosphine Oxides as PreligandsCatalysts with Chiral Self-Assembling P-LigandsP-Ligands with Additional Functional Groups - Concepts of Secondary Interactions and HemilabilityCHIRAL LIGANDS FOR REACTIONS IN ALTERNATIVE MEDIALigands for Catalytic Reactions in Aqueous SystemsLigands for Catalytic Reactions in Fluorous SystemsLigands for Catalytic Reactions in Ionic LiquidsCovalently Anchored P-Ligands and CatalystsMicelle-Based Chiral P-LigandsDendritic Catalysts Based P-LigandsNoncovalently Anchored Catalysts Based on Chiral Phosphine LigandsP-LIGANDS BOUND TO BIOMOLECULESP-Ligands Bound to Proteins: Artificial MetalloenzymesP-Ligands Bound to PeptidesMIXTURES OF MONODENTATE P-LIGANDS IN STEREO- AND REGIOSELECTIVE TRANSITION METAL CATALYSISThe General Concept of Using Mixtures of Monodentate LigandsControlling Enantioselectivity by Using Mixtures of Monodentate P-LigandsCHIRAL TRIVALENT PHOSPHOROUS LIGANDS CATALYSTSKinetic Resolution with Phosphine OrganocatalystsDesymmetrizationAsymmetric Catalytic Reactions of Prochiral Compounds with Phosphine OrganocatalystsGENERAL METHODS FOR THE SYNTHESIS OF CHIRAL TPCSynthesis of P-Stereogenic Phosphines Via Enantioselective AlkylationSynthesis of P-Stereogenic Phosphorous Compounds Based on Chiral Aminoalcohols as Chiral AuxiliaryPractical Routes to Chiral PhospholanesChiral Ligands Made by Asymmetric CatalysisPhosphine Boranes and Related Trivalent P-Compounds as Intermediates in the Syntheses of Chiral Ligands and OrganocatalystsParallel Synthesis of Chiral P-LigandsCONTROLLING REGIO- AND STEREOCHEMISTRY IN METAL-CATALYZED AND METAL-MEDIATED REACTIONS WITH THE AID OF SUBSTRATE-BOUND REAGENT-DIRECTING PHOSPHINE GROUPSDesign and Preparation of the Reagent-Directing o-DPPB GroupApplication in Directed Hydroformylationo-DPPB-Directed Atropdiastereoselective Biarylcouplingo-DPPB-Directed Palladium-Catalyzed Allylic Substitutiono-DPPB- and o-DPPB-Directed Allylic Substitution with Organocopper ReagentsCHARACTERIZATION OF P-LIGANDS METAL COMPLEXESNMR Spectroscopic MethodsProperties of Phosphorous LigandsINDUSTRIAL ASPECTSThe Role of Chiral Phosphines as LigandsThe Difficult Task of Finding the Right Chiral CatalystThe Major Suppliers of Chiral Ligands and Related ServicesCommercially Available Chiral Ligands with Established Industrial PerformanceTechnological AspectsHandling of IP Rights and Licensing for Production
About the author
Born 1954 Professor Börner finished his thesis in 1984. After several years of postdoctoral studies and industrial experience he moved to Rostock. Now, Professor Börner is head of department for asymmetric catalysis in Rostock and published over 140 scientific papers, reviews, book chapters and patents. He was awarded the departmental price for organic chemistry of the AdW, The Otto-Röhm price and the Descartes price of the European Union.
Summary
Nahezu alle namhaften Fachleute auf dem Gebiet der Katalyse mit Phosphorverbindungen haben zu diesem dreibändigen Standardwerk beigetragen. Der übersichtlich nach Substanzklassen geordnete Text führt den Leser in die wichtigsten Anwendungen in der asymmetrischen Katalyse ein. Zahlreiche Beispiele, unter anderem aus der Naturstoffsynthese und Wirkstoffforschung, zeigen die praktische Umsetzung der besprochenen Strategien. Informationen zu einer Auswahl typischer Phosphorverbindungen wurden in einem Anhang zusammengefasst.
