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From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
List of contents
INTRODUCTIONAdministrative Optimization of Proteomics Networks for Drug DevelopmentProteomic Data Standardization, Deposition and ExchangePROTEOMIC TECHNOLOGIESDifference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical ResearchBiological Mass Spectrometry: Basics and Drug Discovery Related ApproachesMultidimensional Column Liquid Chromatography (LC) in ProteomicsPeptidomics Technologies and Applications in Drug ResearchProtein Biochips in the Proteomic FieldCurrent Developments for the In Vitro Characterization of Protein InteractionsAPPLICATIONSMolecular Networks in Morphologically Intact Cells and Tissue-Challenge for Biology and Drug DevelopmentFrom Target to Lead SynthesisDifferential Phosphoproteome Analysis in Medical ResearchBiomarker Discovery in Renal Cell Carcinoma Applying Proteome-Based Studies in Combination with SerologyStudies of Drug Resistance Using Organelle ProteomicsClinical Neuroproteomics of Human Body Fluids: CSF and Blood Assays for Early and Differential Diagnosis of DementiaProteomics in Alzheimer's DiseaseCardiac ProteomicsInnovation Processes
About the author
All six editors are Researchers at the Medical Proteom-Center hosted by the University of Bochum (Germany). This international research center was established in 2002 under the leadership of Helmut E. Meyer, a co-founder of the Protagen AG. Professor Meyer is also initiator and coordinator of the Human Brain Proteome Project within the German National Genome Research Net (NGFN) as well as of the Brain Proteome Project within the Human Proteome Organisation (HUPO BPP).
Summary
From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.
Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.
Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.
Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Report
"Zahlreiche Beiträge von Experten aus der pharmazeutischen Industrie und wissenschaftlichen Proteomics-Zentren vermitteln dem Leser in diesem Band einen Eindruck von den gegenwärtigen Entwicklungen und Perspektiven auf diesem hochinteressanten Gebiet. ... Erwähnenswert ist die große Anzahl von Literaturzitaten, ... enthält dieses Handbuch alle Informationen, die ein professioneller Proteomics-Anwender braucht und ist damit für pharmazeutische und medizinische Chemiker, sowie Molekularbiologen und Gentechnologen von großem Wert." Pharmazie in unserer Zeit
