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This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis.A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.
List of contents
PrefaceBIOACTIVE ALKALOIDS: STRUCTURE AND BIOLOGYEcological Roles of AlkaloidsAntitumor Alkaloids in Clinical Use or in Clinical TrialsAlkaloids and the Bitter TasteCapsaicin and CapsaicinoidsGlycosidase-Inhibiting Alkaloids: Isolation, Structure, and ApplicationNeurotoxic Alkaloids from CyanobacteriaLamellarin Alkaloids: Structure and Pharmacological PropertiesManzamine AlkaloidsAntiangiogenic Alkaloids from Marine OrganismsA Typical Class of Marine Alkaloids: BromopyrrolesGuanidine Alkaloids from Marine InvertebratesNEW TRENDS IN ALKALOID ISOLATION AND STRUCTURE ELUCIDATIONAnalysis of Tropane Alkaloids in Biological MatricesLC-MS of Alkaloids: Qualitative Profiling, Quantitative Analysis, and Structural IdentificationApplications of 15NNMR Spectroscopy in Alkaloid ChemistryNEW TRENDS IN ALKALOID SYNTHESISSynthesis of Alkaloids by Transition Metal Mediated Oxidative CyclizationsCamptothecin and Analogues: Structure and Synthetic EffortsCombinatorial Synthesis of Alkaloid-like Compounds In Search of Chemical Probes of Protein-Protein InteractionsDaphniphyllum Alkaloids: Structures, Biogenesis, and ActivitiesStructure and Biosynthesis of Halogenated AlkaloidsEngineering Biosynthetic Pathways to Generate Indolocarbazole Alkaloids in Microorganisms
About the author
Ernesto Fattorusso was assistant professor at the University of Naples (1963-75); in 1975 he became full Professor of Organic Chemistry at the Faculty of Science. In 1980 he moved to the Faculty of Pharmacy, where he was elected Dean twice. In 2002 he won the A. Quilico Award (Società Chimica Italiana) and in 2004 the P. Scheuer Award (Akademie of Erfurt). He has published more than 300 research papers.
Orazio Taglialatela Scafati got the Ph.D. in "Bioactive Natural Products" in 1997, under the supervision of Prof. Fattorusso. Currently, he is Associate Professor in Organic Chemistry, Faculty of Pharmacy, University of Naples "Federico II".
His research interests deal with isolation, structure elucidation and semisynthetic transformations of bioactive secondary metabolites from marine invertebrates and terrestrial plants. He is the author of 45 research papers and the editor of the book "Flavour and Fragrance Chemistry".
Summary
This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis.
A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.
Report
"Ich kann daher Modern Alkaloids allen an der Naturstoffchemie interessierten empfehlen."Angewandte Chemie2008-120/15
