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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.
The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.
Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
List of contents
Section I: Overview
1. Epigenetics of Personalized Medicine
Section II: Epigenetic Variations Among Individuals
2. Inter-individual Variability of DNA Methylation
3. Differences in Histone Modifications Between Individuals
4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape
5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation
Section III: Bioinformatics of Personalized Epigenetics
6. Computational Methods in Epigenetics
Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine
7. Epigenetic Biomarkers in Personalized Medicine
8. Epigenetic 'Fingerprint'
9. Epigenetics of Personalized Toxicology
Section V: Environmental Personalized Epigenetics
10. Environmental Contaminants and their Impacts on the Epigenome
11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics
Section VI. Pharmacology and Drug Development of Personalized Epigenetics
12. Personalized Pharmacoepigenomics
13. Personalized Medicine and Epigenetic Drug Development
Section VII: Personalized Epigenetics of Disorders and Disease Management
14. Epigenetics and Personalized Pain Management
15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management
16. Epigenetic Modification of miRNAs in Cancer
17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches
18. Cardiovascular Diseases and Personalized Epigenetics
Section VIII: Challenges and Future Directions
19. Future Challenges and Prospects for Personalized Epigenetics
About the author
Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
