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The best of enzymatic and organic synthesis.In nature, enzymes are able to catalyze reaction sequences and cascades without the need for purification and isolation of intermediates. This is one essential advantage compared to the classical chemical multi-step reactions. In multi-step enzyme catalysis, researchers copy this elegant method to make biocatalysis more effective and elegant. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques open the door for hitherto unknown reactions.This first comprehensive coverage of the topic provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more.From the contents: Multi-Enzyme Synthesis of Glycoconjugates Multimodular Syntheses Modifying the Glycosilation Pattern in Microorganisms Chemoenzymatic Routes to Enantiomerically Pure Amines and Amino acids Asymmetric Transformations by Couples Enzymes and Metal Catalysis Engineering Novel Biosynthetic Pathways to Produce New Chemical Compounds Synthesis of Intermediates of Pharmaceutical Interest Oxidizing Enzymes into Multi-Enzyme Biotransformation Processes Host-Intrinsic Enzyme Activities in Recombinant Whole-Cells Catalyzed Processes Microbial Production of DNA Building Blocks Enzyme Initiation of Asymmetric Cascade-Reactions The Biotransformations Approach for Multi-Step Processes Chemoenzymatic Synthesis of Homogeneous Glycoprotein Aldolases Catalyzed C-C Bond Formation in the Core of Multi-Step ProcessesOf great interest to all those working in the pharmaceutical and fine chemical industries.
List of contents
Multi-Enzyme Synthesis of GlycoconjugatesMultimodular Synthases as Tools of the Synthetic ChemistModifying the Glycosilation Pattern in Microorganisms by Combinatorial BiosynthesisChemoenzymatic Routes to Enantiomerically Pure Amines and AminoacidsAsymmetric Transformations by Couples Enzymes and Metal CatalysisEngineering Novel Biosynthetic Pathways to Produce New Chemical CompoundsBiocatalysis and Chemical Catalysis for the Synthesis of Intermediates of Pharmaceutical InterestOxidizing Enzymes into Multi-Enzyme Biotransformation ProcessesThe Role of Host-Intrinsic Enzyme Activities in Recombinant Whole-Cells Catalyzed ProcessesMicrobial Production of DNA Building BlocksEnzyme Initiation of Asymmetric Cascade-ReactionsThe System of Biotransformations Approach for Multi-Step ProcessesChemoenzymatic Synthesis of Homogeneous GlycoproteinAldolases Catalyzed C-C Bond Formation in the Core of Multi-Step Processes
About the author
Eduardo García-Junceda received his PhD at the Plant Physiology Department at the University of Madrid. He joined Chi-Huey Wong's Group at The Scripps Research Institute (La Jolla, California) as postdoctoral fellow. After his return to Spain in 1995, he was appointed Research Staff Member in the Institute of Organic Chemistry of CSIC in 1997. His research interests concentrate on molecular biology applied to organic synthesis and enzyme catalysis.
Summary
The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.
Report
?This book is recommended to organic chemists, biochemists, chemical engineers, microbiologists, and all researchers who are interested in the fundamentals and applications of biocatalysis.?( The Quarterly Review of Biology , September 2009)
