Read more
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail.Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include:Historical backgroundDistinct structures and functionsStructural basisSignalingViral entry and virion buddingCholesterol transportCaveolinsLipid shellsCell polarity and intracellular traffickingCancer cellsOf prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
List of contents
Lipid Rafts, Caveolae, and Membrane TrafficThe Forces that Shape CaveolaeThe Biophysical Characterization of Lipid RaftsThe Role of Caveolae and Noncaveolar Rafts in EndocytosisRole of Cholesterol in Signal Transduction from CaveolaePhosphorylation of Caveolin and Signaling from CaveolaeRole of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane SignalingCaveolin and its Role in Intracellular Chaperone ComplexesThe Roles of Caveolae and Caveolin in Cell Shape, Locomotion, and Stress Fiber FormationLipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor ProteinCaveolae and the Endothelial Nitric Oxide SynthaseThe Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression
About the author
Christopher J. Fielding is Neider Professor of Cardiovascular Physiology at the University of California at San Francisco (UCSF). He graduated from University College in London (UK) where he also received his PhD. After appointments at Oxford University and at the University of Chicago, he joined the faculty at UCSF in 1971, being appointed full professor in 1985. Professor Fielding's main research interest is in the trafficking of cholesterol, its regulation and its role in signal transduction.
Summary
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail.
Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include:
Historical background
Distinct structures and functions
Structural basis
Signaling
Viral entry and virion budding
Cholesterol transport
Caveolins
Lipid shells
Cell polarity and intracellular trafficking
Cancer cells
Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
Report
"...Eine sehr gute Übersicht zum Thema bei angemessenem Preis."BDI, 06/2007
