Cellular and Biomolecular Recognition - Synthetic and non-Biological Molecules

With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine.The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.

List of contents

DEVELOPMENT OF FUNCTIONAL MATERIALS FROM ROD-LIKE VIRUSESIntroductionOverviewProgrammable Protein ShellsTemplated Syntheses of Composite MaterialsSelf-Assembly of Rod-Like VirusesVirus-Based Device and ApplicationsOutlookBIOMIMETIC NANOPARTICLES PROVIDING MOLECULARLY DEFINED BINDING SITES - PROTEIN-FEATURING STRUCTURES VERSUS MOLECULARLY IMPRINTED POLYMERSIntroductionCore Materials and FunctionalitiesFunctional ShellsApplicationsProductsConclusionsINTERACTION BETWEEN SILICA PARTICLES AND HUMAN EPITHELIAL CELLS: ATOMIC FORCE MICROSCOPY AND FLUORESCENCE STUDYInteraction of Silica with Biological Cells: BackgroundInteraction of Silica Particle with the Cell Surface: How it is Seen with AFMUltra-Bright Fluorescent Silica Particles to be Used to Study Interaction with CellsUltra-Bright Fluorescent Silica Particles to Distinguish Between Cancer and Normal CellsCHIRAL MOLECULAR IMPRINTING AS A TOOL FOR DRUG SENSINGIntroductionElectrochemical Drug SensorsOptical Drug SensorsMass Drug SensorsCATALYTIC ANTIBODIES FOR SELECTIVE CANCER CHEMOTHERAPYIntroductionCatalytic Antibodies Designed for Prodrug ActivationCatalytic Antibody 38C2 and Cancer TherapyChemically Programmed AntibodiesNATURAL AND SYNTHETIC STIMULATORS OF THE IMMUNE RESPONSEIntroductionLipopolysaccharide Endotoxin - A Potent Immunostimulatory MoleculeLPS RecognitionSeptic ShockLPS BiosynthesisMinimal Modified Lipid AIsolation of "Natural" Kdo2-Lipid ASynthetic LPS, Lipid A and Their UsesStructural StudiesBacterial LPS-Binding ProteinsSphingolipids - Essential Membrane Components of Mammals, Plants, Fungi, Yeast and BacteriaNatural Killer T Cells and GSLsGSL AntigensStructure - Activity RelationshipsSaccharide ModificationCeramide ModificationHigh-Resolution Structural Analysis of Receptor-GSL ComplexesSUPRAMOLECULAR ASSEMBLIES OF POLYDIACETYLENES FOR BIOMOLECULAR SENSING: COLORIMETRIC AND "TURN-ON" FLUORESCENCE APPROACHESIntroductionVesicular PDA Sensors for Colorimetric Signaling of Bacterial Pore-Forming ToxinFabrication of "Turn-On" Fluorescence Vesicle Sensors with PDAs"Mix-and-Detect" Type of "Turn-On" Fluorescence Sensor for Bacterial ToxinMULTIVALENT SYNTHETIC RECEPTORS FOR PROTEINSAminopyrazoles for Beta-Sheet Capping in Protein Misfolding EventsNew Mechanisms of Enzyme Inhibition by Molecular Clips and TweezersProtein Surface Recognition by Tailor-Made PolymersANALYSIS OF BIOLOGICAL INTERACTIONS AND RECOGNITIONS BY SURFACE PLASMON RESONANCEIntroduction to Surface Plasmon Resonance TechnologyWorking Principle of SPRSensor Surface Chemistry and Its FabricationsImportant Factors Impacting on the Performance of SPR-Based Analyses of Biological Interactions on the Nonbiological Transducer SurfaceLocalized SPR of Inorganic Nanoparticles for Analyses of Biological InteractionMEMBRANE-ACTIVE NATURAL AND SYNTHETIC PEPTIDES AND PEPTIDOMIMETICSIntroductionMode of Action of Membrane-Active PeptidesNatural PeptidesSynthetic PeptidesPeptidomimeticsLUMINESCENT QUANTUM DOT FLUORESCENCE RESONANCE ENERGY TRANSFER-BASED PROBES IN CELLULAR AND BIOLOGICAL ASSAYSIntroductionLuminescent QDsFRETQD FRET-Based Protease ProbesNEW PROTEINS FOR NEW SENSING METHODOLOGIES: THE CASE OF THE PROTEIN-BINDING FAMILYIntroductionGalactose/Glucose-Binding Protein from Escherichia ColiGlutamine-Binding Protein from E. ColiTrehalose/Maltose-Binding Protein from the Hyperthermophilic Archaeon Thermococcus LitoralisLipocalins and Odorant-Binding ProteinMETHODS OF ANALYSIS FOR IMAGING AND DETECTING IONS AND MOLECULESFluorescent and Luminescent ProteinsFunctional PeptidesRepresentative Technologies for Molecular Imaging

About the author

Currently at the department of chemistry at Ben Gurion University, Israel, Raz Jelinek obtained his BSc in chemistry from the Hebrew University of Jerusalem, Israel, and his PhD from the University of California, Berkeley. He was a Cancer Research Institute post-doctoral fellow at the University of Pennsylvania, and is currently a Visiting Professor at the Department of Chemical and Biomolecular Engineering at Johns Hopkins University. Professor Jelinek has over 80 scientific publications and 10 patents to his name, and has received several scientific awards, including the Roger-Siegel-Brown Award of the Israeli Academy of Science and the Ruth L. Kirschstein National Research Service Award of the National Institutes of Health, USA.

Summary

With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine.
The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.

Report

"The various contributors to this book provide novel experimental approaches and insights toward biomolecular recognition in biological systems." ( JACS Reviews , 2010)

Product details

• Authors: Raz Jelinek
• Assisted by: Ra Jelinek (Editor), Raz Jelinek (Editor)
• Publisher: Wiley-VCH
• Languages: English, German
• Product format: Hardback
• Released: 31.03.2015
• EAN: 9783527322657
• ISBN: 978-3-527-32265-7
• No. of pages: 349
• Dimensions: 179 mm x 246 mm x 23 mm
• Weight: 854 g
• Illustrations: 129 SW-Abb., 19 Farbabb., 9 Tabellen
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Organische Chemie, ORGANIC CHEMISTRY, Biowissenschaften, Biologie, Life Sciences, Biowissenschaften, biotechnology, chemistry, Biotechnologie i. d. Biowissenschaften, Biomolecules (DNA, RNA, Peptides, etc.), Biomoleküle (DNA, RNA, Peptide)