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Informationen zum Autor Jeremy R. Everett , Ph.D., Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich, UK John C. Lindon , Ph.D., Imperial College London, UK Ian D. Wilson , Ph.D., Imperial College London, UK Robin Harris , Ph.D., Department of Chemistry, University of Durham, UK Klappentext NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. Zusammenfassung NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. Inhaltsverzeichnis Contributors xi Series Preface xvii Preface xix Part A: Introduction 1 1 Drug Discovery and Development: The Role of NMR Jeremy R. Everett 3 Part B: NMR Theory & Experimental Methods 21 2 Modern NMR Pulse Sequences in Pharmaceutical R&D John A. Parkinson 23 3 Experimental NMR Methods for Pharmaceutical Research and Development Anthony C. Dona 41 4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies John C. Lindon and Ian D. Wilson 53 5 Quantitative NMR Spectroscopy in Pharmaceutical R&D Ulrike Holzgrabe 63 6 High-throughput NMR in Pharmaceutical R&D John C. Hollerton 79 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research Kirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89 Part C: Idea to Lead 103 8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&D Krishna Saxena and Harald Schwalbe 105 9 High-resolution MAS NMR of Tissues and Cells Leo L. Cheng 117 10 NMR Studies of Inborn Errors of Metabolism Sarantos Kostidis and Emmanuel Mikros 131 11 NMR-based Structure Confirmation of Hits and Leads in Pharmaceutical R&D Philip J. Sidebottom 147 12 Fragment-based Drug Design Using NMR Methods Leonor Puchades-Carrasco and Antonio Pineda-Lucena 155 13 Hit Discovery from Natural Products in Pharmaceutical R&D Olivia Corcoran 173 Part D: Lead to Drug Candidate 183 14 NMR-based Structure Determination ...
