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This first comprehensive overview of the rapidly growing field emphasizes the use of hydrogen bonding as a tool for organic synthesis, especially catalysis. As such, it covers such topics as enzyme chemistry, organocatalysis and total synthesis, all unified by the unique advantages of hydrogen bonding in the construction of complex molecules from simple precursors.Providing everything you need to know, this is a definite must for every synthetic chemist in academia and industry.
List of contents
PrefaceINTRODUCTIONIntroductionHydrogen Bonding in Organic SynthesisHYDROGEN-BOND CATALYSIS OR BRONSTED-ACID CATALYSIS? GENERAL CONSIDERATIONSIntroductionWhat is the Hydrogen Bond?Hydrogen-Bond Catalysis or Bronsted-Acid CatalysisBronsted-Acid CatalysisHydrogen-Bond CatalysisCOMPUTATIONAL STUDIES OF ORGANOCATALYTIC PROCESSED BASED ON HYDROGEN BONDINGIntroductionDynamic Kinetic Resolution (DKR) of Azlactones-Thioureas Can Act as Oxyanion Holes Comparable to Serine HydrolasesOn the Bifunctionality of Chiral Thiourea-Tert-Amine-Based Organocatalysts: Competing Routes to C-C Bond Formation in a Michael AdditionDramatic Acceleration of Olefin Epoxidation in Fluorinated Alcohols: Activation of Hydrogen Peroxide by Multiple Hydrogen Bond NetworksTADDOL-Promoted Enantioselective Hetero-Diels-Alder Reaction of Danishefsky's Diene with Benzaldehyde - Another Example for Catalysis by Cooperative Hydrogen BondingEpilogOXYANION HOLES AND THEIR MIMICSIntroductionWhat are Oxyanion Holes?A More Detailed Description of the Two Classes of Oxyanion Holes in EnzymesOxyanion Hole MimicsConcluding RemarksBRONSTED ACIDS, H-BOND DONORS, AND COMBINED ACID SYSTEMS IN ASYMMETRIC CATALYSISIntroductionBronsted Acid (Phosphoric Acid and Derivatives)N-H Hydrogen Bond CatalystsCombined Acid Catalysis(THIO)UREA ORGANOCATALYSTSIntroduction and BackgroundSynthetic Applications of Hydrogen-Bonding (Thio)urea OrganocatalystsSummary and OutlookHIGHLIGHTS OF HYDROGEN BONDING IN TOTAL SYNTHESISIntroductionIntramolecular Hydrogen Bonding in Total SynthesesIntermolecular Hydrogen Bondings in Total SynthesesConclusions
About the author
After a postdoctoral stay with K. C. Nicolaou, Petri Pihko joined the faculty of Helsinki University of Technology, where his group was awarded the "Outstanding Junior Research Group" award of the University in 2004. His current research interests include organocatalysis, catalyst design, and total synthesis.
Summary
This first comprehensive overview of the rapidly growing field emphasizes the use of hydrogen bonding as a tool for organic synthesis, especially catalysis. As such, it covers such topics as enzyme chemistry, organocatalysis and total synthesis, all unified by the unique advantages of hydrogen bonding in the construction of complex molecules from simple precursors.
Providing everything you need to know, this is a definite must for every synthetic chemist in academia and industry.
Report
"Hydrogen Bonding in Organic Synthesis is well organized and delivered in a way easy for every synthetic chemist in academia and industry to understand." (Current Engineering Practice, 1 November 2010) "The material is well-organized and recent." ( JACS Reviews, 2010)
