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Informationen zum Autor Valentin Gribkoff is an Associate Professor Adjunct in the Department of Internal Medicine at Yale University School of Medicine and is a founding member of The Northwoods Group, a biotech consulting and development consortium. He previously co-edited Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels (Wiley, 2009) and is a co-editor of the Wiley Series on Neuropharmacology. Elizabeth Jonas is an Associate Professor at the Departments of Internal Medicine, Section of Endocrinology, and Neurobiology at Yale University School of Medicine. J. Marie Hardwick is the David Bodian Professor of Molecular Microbiology and Immunology at The Johns Hopkins Bloomberg School of Public Health. Klappentext This book presents advances in the field of neuronal mitochondria - functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases.* Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death* Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments* Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field* Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders Zusammenfassung This book presents advances in the field of neuronal mitochondria functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. Inhaltsverzeichnis Contributors xiv Preface xviii Section I Mitochondrial Structure and Ion Channels 1 1 Mitochondrial Permeability Transition: A Look From a Different Angle 3 Nickolay Brustovetsky 1.1 Regulation of Intracellular Calcium in Neurons 3 1.2 Calcium Overload and Mitochondrial Permeability Transition 4 1.3 The Mitochondrial Transition Pore 8 1.3.1 Evidence for ANT and VDAC as Components of the PTP 8 1.3.2 Alternative Hypotheses of mPTP Composition 17 Acknowledgments 22 References 22 2 The Mitochondrial Permeability Transition Pore, the c ?] Subunit of the F1FO AT P Synthase, Cellular Development, and Synaptic Efficiency 31 Elizabeth A. Jonas, George A. Porter, Jr., Gisela Beutner, Nelli Mnatsakanyan and Kambiz N. Alavian 2.1 Introduction 32 2.2 Mitochondria at the Center of Cell Metabolism and Cell Death 32 2.3 Mitochondrial Inner Membrane Leak: Regulator of Metabolic Rate and Uncoupling 32 2.4 Mitochondrial Inner Membrane Channels and Exchangers are Necessary for Ca2+ Cycling and Cellular Ca2+ Dynamics 33 2.5 Mitochondrial Inner and Outer Membrane Channel Activity Regulates Ca2+ Re?]Release from Mitochondria after Buffering 34 2.6 Bcl?]2 Family Proteins Regulate Pathological Outer Mitochondrial Membrane Permeabilization (MOMP) 35 2.7 Pathological Inner Membrane Depolarization: Mitochondrial Permeability Transition 36 2.8 The Quest for an Inner Membrane Ca2+?]Sensitive Uncoupling Channel: The PT Pore 37 2.8.1 Electrophysiologic Properties of the mPTP 37 2.8.2 Characterization of a Molecular Complex Regulating the Pore 39 2.8.3 Bcl?]xL Regulates Metabolic Effi...
