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Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. Thus, several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia. Given our intention that the book be useful to clinicians, we pay particular attention to these advances, to management of acute leukemia in general, and to development of new therapies.
List of contents
Acute Myeloid Leukemia.- Therapy of AML.- Diagnosis and Classification of the Acute Myeloid Leukemias (with Discussion of the Role of the Myelodysplastic Syndromes in AML Pathogenesis).- Acute Myeloid Leukemia: Epidemiology and Etiology.- Relapsed and Refractory Acute Myeloid Leukemia.- Acute Lymphoblastic Leukemia.- Acute Lymphoblastic Leukemia: Epidemiology and Etiology.- Molecular Biology and Genetics.- Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification.- Diagnosis of Acute Lymphoblastic Leukemia.- General Approach to the Therapy of Adult Acute Lymphoblastic Leukemia.- Recent Clinical Trials in Acute Lymphoblastic Leukemia by the Cancer and Leukemia Group B.- Conventional Therapy in Adult Acute Lymphoblastic Leukemia: Review of the LALA Program.- ALL Therapy: Review of the MD Anderson Program.- Treatment of Adult ALL According to Protocols of the German Multicenter Study Group for Adult ALL (GMALL).- Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.- Burkitt's Acute Lymphoblastic Leukemia (L3ALL) in Adults.- Treatment of Lymphoblastic Lymphoma in Adults.- The Role of Allogeneic Stem Cell Transplantation in the Therapy of Adult Acute Lymphoblastic Leukemia (ALL).- The Role of Autologous Stem Cell Transplantation in the Management of Acute Lymphoblastic Leukemia in Adults.- Novel Therapies in Acute Lymphoblastic Leukemia.- Minimal Residual Disease Studies in Acute Lymphoblastic Leukemia.- Central Nervous System Involvement in Adult Acute Lymphocytic Leukemia.- Relapsed Acute Lymphoblastic Leukemia.- Emergencies in Acute Lymphoblastic Leukemia.- Erratum.- Erratum.
Summary
As research into cancers progresses, scientists are becoming ever more aware that better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.
