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Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.
List of contents
The Cell Types and the Matrix.- Hepatocytes.- Signaling Pathways in Biliary Epithelial Cells.- Stellate Cells.- Signaling Pathways in Liver Diseases Kupffer Cells.- Hepatic Sinusoidal Endothelial Cells.- Extracellular Matrix.- Platelets: A New Cell Type in Liver Physiology.- Immune Cell Communication and Signaling Systems in Liver Disease.- The Pathways.- Toll-Like Receptors.- TNF/TNF Receptors.- Fas/FasL.- Interferon Signaling.- NF-?B.- JNKs in liver diseases.- Insulin Pathway.- Role of PKB/Akt in Liver Diseases.- Targeting mTOR Signaling Pathways in Liver Disease.- AMP-Activated Protein Kinase in Liver.- ER Stress Signaling in Hepatic Injury.- PPAR?, A Key Regulator of Hepatic Energy Homeostasis in Health and Disease.- Bile Acids and Their Receptors.- Signaling Pathways in Liver Diseases: PXR and CAR.- p53.- The MYC Network and Cancer.- The WNT/?-Catenin Pathway.- Sonic Hedgehog Pathway.- Hypoxia-Inducible Factor-1 Signaling System.- VEGF Signaling.- Apoptosis and Mitochondria.- Calcium Signaling.- HBV Signaling.- Hepatitis C Virus and Insulin Signaling.- MicroRNAs.- Hepatic Clocks.
Summary
Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.
