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Post-transplant lymphoproliferative disorders are a group of conditions that straddle the borders between infection and malignancy. They were very rare prior to the mid-1980s but now can be expected to develop in 1-10% of transplant recipients. While some cases are reversible with reduction in immunosuppression, more severe forms are indistinguishable from frank lymphomas.
This book sets out to cover in depth every aspect of these disorders, including both basic science and clinical topics. The epidemiology is reviewed, and careful attention is paid to the role of Epstein-Barr virus in their development. Clinical features are documented and clear guidance is provided on diagnosis, with thorough description of pathologic and imaging findings. Further chapters are devoted to treatment, prognosis, preventive and pre-emptive strategies, and organ-specific considerations.
The state-of-the-art information contained in this book will aid researchers as well as the many different professionals involved in caring for patients with post-transplant lymphoproliferative disorders. The comprehensive and detailed coverage will appeal to those who already have some expertise in the field, yet the book will also serve as an invaluable resource for beginners in transplantation.
List of contents
Historical Perspective on the Early Studies of Posttransplant Lymphoproliferative Disorders (PTLD).- Epidemiology of PTLD.- The Biology of Epstein-Barr Virus and Posttransplant Lymphoproliferative Disease.- Epstein-Barr Viral Load Testing: Role in the Prevention, Diagnosis and Management of Posttransplant Lymphoproliferative Disorders.- Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder.- Pathology.- Prognostic Factors for PTLD.- Treatment of PTLD.- Prevention of Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disease Following Transplantation.- Organ Specific Issues of PTLD - Kidney.- Posttransplantation Lymphoproliferative Disorder (PTLD) in Liver and Small Bowel Transplant Recipients.- Heart and Lung Transplantation.- Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT).- Research Priorities and Future Directions.
Summary
Post-transplant lymphoproliferative disorders are a group of conditions that straddle the borders between infection and malignancy. They were very rare prior to the mid-1980s but now can be expected to develop in 1-10% of transplant recipients. While some cases are reversible with reduction in immunosuppression, more severe forms are indistinguishable from frank lymphomas.
This book sets out to cover in depth every aspect of these disorders, including both basic science and clinical topics. The epidemiology is reviewed, and careful attention is paid to the role of Epstein-Barr virus in their development. Clinical features are documented and clear guidance is provided on diagnosis, with thorough description of pathologic and imaging findings. Further chapters are devoted to treatment, prognosis, preventive and pre-emptive strategies, and organ-specific considerations.
The state-of-the-art information contained in this book will aid researchers as well as the many different professionals involved in caring for patients with post-transplant lymphoproliferative disorders. The comprehensive and detailed coverage will appeal to those who already have some expertise in the field, yet the book will also serve as an invaluable resource for beginners in transplantation.
Additional text
From the reviews:
“The authors present a comprehensive overview of the presentation, diagnosis, and management of post-transplant lymphoproliferative disorders (PTLD) and post-transplant Epstein-Barr virus (EBV) infection. … This work will prove useful to all physicians who care for transplant recipients. … It will certainly prove a useful contribution.” (Truman M. Earl, Doody’s Review Service, March, 2010)
Report
From the reviews: "The authors present a comprehensive overview of the presentation, diagnosis, and management of post-transplant lymphoproliferative disorders (PTLD) and post-transplant Epstein-Barr virus (EBV) infection. ... This work will prove useful to all physicians who care for transplant recipients. ... It will certainly prove a useful contribution." (Truman M. Earl, Doody's Review Service, March, 2010)
