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Different Pearson mutual-positive-correlation TERF1/USP14/CCRK/BEST1-repressive molecular network was constructed from the overlapping of GRNInfer and Pearson under TERF1/USP14/CCRK/BEST1 CC -0.25 in high human left hemisphere compared with low chimpanzee left hemisphere, respectively. We propose high TERF1 inside-outside-in inhibitive estrogen induced morphogenesis through LGALS3BP-SELENBP1-CA2-GSTM3; High USP14 feedback-inhibitive axon, T cell-induced microtubule complex through MAPT-RASGRP1-RFK-AF052119-M19267; High CCRK inside-out inhibiting DNA damage induced mitotic spindle through CLCN4-MIA3-CDKN1B-KPNB1-PSMA4-SMG1-AGL; High BEST1-inhibited nucleus actin cytoskeleton organization through CAMTA1-EID1-PDE4DIP-NR1D2 in high human left hemisphere based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases. They are very useful to develop a new route and identify novel markers and potential drugs for prognosis and therapy.
About the author
Prof. Dr. Lin Wang has received her Ph.D in Klinik für Innere Medizin, Friedrich-Schiller-Universität Jena, Germany. Currently, she is working as Biomedical Center professor in Beijing University of Posts and Telecommunications (BUPT).
