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Informationen zum Autor Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA. Klappentext Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer! aging! neurodegeneration! immunology! and infectious diseases. Comprehensive and up-to-date! this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. . Volume 7 provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; and the role of autophagy in apoptosis. Attention is given to autophagy in the cardiovascular system! with particular insights into the role of autophagy in atherosclerosis and the distinctive behavior of autophagy in the sinoatrial node. Cutting-edge findings in the relationships between autophagy and lifestyle are explored with the regulation of macroautophagy in response to exercise! as well as the promotion of carcinogenesis via autophagy in response to cigarette smoking. . Volume 7 highlights the importance of understanding the role of autophagy in context! as the complexity of autophagic function becomes increasingly clear. Autophagy may be differentially regulated! and may perform distinctive cell-specific functions even within a single tissue. The overall significance of autophagy thus cannot be oversimplified! and must be explored with granular detail of the specific role! function! and area of impact.This book is an asset to newcomers as a concise overview of the complex significance of autophagy! while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. . Volumes in the Series . Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes! including cellular development and differentiation! cancer! immunity! infectious diseases! inflammation! maintenance of homeostasis! r ...
List of contents
Chapter 1. Introduction
I. AUTOPHAGOSOME BIOGENESIS AND REGULATION
Chapter 2. Role of endoplasmic reticulum in the formation of phagophores / autophagosomes: three-dimensional morphology
Joanna Biazik, Helena Vihinen, Eija Jokitalo, Eeva-Liisa Eskelinen
Chapter 3. The nucleus-vacuole junction in saccharomyces cerevisiae
Angela Cadou and Andreas Mayer
Chapter 4. Human Wipis as phosphoinositide effectors at the nascent autophagosome: a robust tool to assess macroautophagy by quantitative imaging
Zsuzanna Takacs and Tassula Proikas-Cezanne
Chapter 5. Induction of autophagy: role of endoplasmic reticulum stress and unfolded protein response
Behzad Yeganeh, Richard Jäger, Adrienne M. Gorman, Afshin Samali and Saeid Ghavami
Chapter 6. Atg16L1 protein regulates hormone secretion independent of autophagy
Koutaro Ishibashi and Mitsunori Fukuda
II. AUTOPHAGY IN PROTEIN QUALITY CONTROL
Chapter 7. Macroautophagy of aggregation-prone proteins in neurodegenerative disease
Leora M. Fox and Ai Yamamoto
Chapter 8. Lithium ameliorates motor disturbance by enhancing autophagy in tauopathy model mice
Yumiko Motoi, Kohei Shimada, and Shin-ei Matsumoto
Chapter 9. Beta-asarone reduces autophagy in a dose-dependent manner and interferes with Beclin 1 function
Yong-Qi Fang and Zhong-Feng Xue
III. AUTOPHAGY AND APOPTOSIS
Chapter 10. Apoptosis and autophagy: The yin-yang of homeostasis in cell death in cancer
Chien-An A. Hu, Kirsten White, Salina Torres, Mohammed-Ali Ishak, Laurel Sillerud, Yubin Miao, Zhihe Liu, Zhenglong Wu, Larry Sklar, and Marianne Berwick
Chapter 11. Role of autophagy and apoptosis in odontogenesis
Lu Zhang and Zhi Chen
Chapter 12. Autophagy is required during monocyte-macrophage differentiation
Yan Zhang, Swati Choksi and Zhenggang Liu
IV. AUTOPHAGY IN THE CARDIOVASCULAR SYSTEM
Chapter 13. Degradation of HSPGS enhances LOX1-mediated autophagy
Shijie Liu, Zufeng Ding, Xianwei Wang, Jawahar L Mehta
Chapter 14. The presence of LC3 and LAMP1 is greater in normal sino-atrial nodal cells than that in ordinary cardiomyocytes, indicating a constitutive event
Mariko Omatsu-Kanbe and Hiroshi Matsuura
V. LIFESTYLE AND AUTOPHAGY
Chapter 15. Regulations of (Macro)-Autophagy in response to exercise
Cécile Jamart and Marc Francaux
Chapter 16. Cigarette smoke promotes cancer via autophagy
Ahmed F. Salem, Federica Stogia, and Michael P. Lisanti
Report
"Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections." --Anticancer Research, February 2015
