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Informationen zum Autor Binghe Wang, PhD, is Regents' Professor of Chemistry and Associate Dean for Natural and Computational Sciences at Georgia State University as well as Georgia Research Alliance Eminent Scholar in Drug Discovery. He is Editor-in-Chief of the journal Medicinal Research Review and founding series editor of the Wiley Series in Drug Discovery and Development. He has published over 230 papers in medicinal chemistry, pharmaceutical chemistry, new diagnostics, and chemosensing. Longqin Hu, PhD, is Professor of Medicinal Chemistry and Director of the Graduate Program in Medicinal Chemistry at Rutgers University. Among his major research interests are the synthesis and evaluation of anticancer prodrugs for the targeted activation in tumor tissues and the discovery of novel small molecule inhibitors of protein-protein interactions. He has published over 80 papers and 8 patents in bioorganic and medicinal chemistry. Teruna Siahaan, PhD, is a Professor and Associate Chair of the Department of Pharmaceutical Chemistry and serves as the Director of the NIH Biotechnology Training Program at the University of Kansas. In addition to co-editing the first edition of Drug Delivery , he has written almost 195 journal papers and book chapters and received the 2014 PhRMA Foundation Award in Excellence in Pharmaceutics. Klappentext Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference.* Helps readers understand progress in drug delivery research and applications* Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics* Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics* Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery Zusammenfassung Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference.* Helps readers understand progress in drug delivery research and applications* Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics* Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics* Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery Inhaltsverzeichnis List of Contributors xvii Preface xxi 1 Factors that Impact the Developability of Drug Candidates 1 Chao Han and Binghe Wang 1.1 Challenges Facing the Pharmaceutical Industry 1 1.2 Factors that Impact Developability 5 1.2.1 Commercial Goal 5 1.2.2 The Chemistry Efforts 6 1.2.3 Biotechnology in the Discovery of Medicine 7 1.2.4 Target Validation in Animal Models 8 1.2.5 Drug Metabolism and Pharmacokinetics 9 1.2.6 Preparation for Pharmaceutical Products 11 1.3 Remarks on Developability 12 1.4 Drug Delivery Factors that Impact Developability 13 References 15 2 Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery 19 Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan 2.1 Introduction 19 2.2 Physiological Barriers to Drug Delivery 20 2.2.1 Paracellular Pathway 22 2.2.2 Transcellular Pathway 25<...
