Drug Discovery for Schizophrenia

Klappentext Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia will cover new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book will outline a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs will emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book will cover new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of opto- and chemogenetic tools for drug discovery in schizophrenia.The combination of these important areas will benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development. Zusammenfassung This book covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. Inhaltsverzeichnis Genetics of schizophrenia: Genome-Wide Association Study; Epigenetics of schizophrenia; Cognitive dysfunction in schizophrenia; Modelling schizophrenia; Glutamate hypothesis of schizophrenia; Dopamine hypothesis of schizophrenia; Neurodevelopmental hypothesis of schizophrenia; Genetic factors and hippocampal dysfunction in schizophrenia; Exome study of schizophrenia; Protein-protein interactions as a potentially new drug target in schizophrenia; Optogenetic approach to dissect neurobiology of schizophrenia; MicroRNAs in neuronal function and dysfunction; Application of pluripotent stem cells in schizophrenia; Deep brain stimulation of the hippocampus and prefrontal cortex as alternative approach in treatment of schizophrenia; Neuroimmunology of brain development in schizophrenia and immunotherapy...

Product details

• Authors: Tatiana Lipina, Tatiana (University of Toronto Lipina, Tatiana V Lipina, Tatiana V (Institute of Physiology and Fun Lipina, Tatiana V Roder Lipina, Tatiana V. Roder Lipina
• Assisted by: John C Roder (Editor), John C. Roder (Editor), Tatiana Lipina (Editor), Tatiana (University of Toronto Lipina (Editor), Tatiana V (Institute of Physiology and Fundamental Medicine Lipina (Editor), Tatiana V. Lipina (Editor), Ana Martinez (Editor), John Roder (Editor), John (Lunenfeld-Tanenbaum Research Institute Roder (Editor), John C (Lunenfeld-Tanenbaum Research Institute Roder (Editor), John C. Roder (Editor), Tatiana V Lipina (Editor), Tatiana V. Lipina (Editor)
• Publisher: Royal Society Of Chemistry
• Languages: English
• Product format: Hardback
• Released: 13.05.2015
• EAN: 9781782620266
• ISBN: 978-1-78262-026-6
• No. of pages: 289
• Series: RSC Drug Discovery; Drug Discovery; Drug Discovery; Drug Discovery Series; RSC Drug Discovery
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Miscellaneous