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Informationen zum Autor Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series. Klappentext Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients! and include syngeneic models! human tumor xenograft models! orthotopic models! metastatic models! and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease! Tumor Models in Cancer Research 2nd edition! provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models! their effective use! and the optimal interpretation of their results. Zusammenfassung The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease. Inhaltsverzeichnis TUMOR MODELS IN CANCER RESEARCH2nd editionBeverly A TeicherTable of ContentsINTRODUCTION1. Perspectives on the History and Evolution of Tumor ModelsShannon Decker and Edward SausvilleTRANSPLANTABLE SYNGENEIC RODENT TUMORS2. Murine L1210 and P388 LeukemiasWilliam R Waud3. Transplantable Syngeneic Rodent TumorsLisa Polin, Thomas H. Corbett, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner, Stuart Hazeldine, Richard Moore, James Rake, and Jerome P. Horwitz4. B16 Murine Melanomas : Historical Perspective on the Development of a Solid Tumor ModelEnrique AlvarezHUMAN TUMOR XENOGRAFTS5. Human Tumor Xenograft Efficacy ModelsMing Liu and Daniel Hicklin6. Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real TimeRobert M. Hoffman7. Patient-derived Tumor Models and ExplantsHeinz-Herbert Fiebig and Angelika M. Burger8. The Pediatric Preclinical Testing ProgramChristopher L. Morton and Peter J. Houghton9. Imaging Efficacy in Tumor ModelsVinod Kaimal, Wilbur R. Leopold, and Patrick McConvilleCARCINOGEN-INDUCED TUMORS10. Mammary Cancer in RatsHenry J. ThompsonDISEASE AND TARGET-SPECIFIC MODELS11. Animal Models of MelanomaEne T. Fairchild and William E. Carson, III12. Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic ApproachesGilda G. Hillman13. Animal Models of MesotheliomaHarvey I. Pass, Joseph B. Pincus Michele Carbone, and Magdalena Plasilova14. The Use of Mouse Models to Study Leukemi /Lymphoma and Assess Therapeutic ApproachesWilliam Siders15. Spontaneous Companion Animal (Pet) CancersDavid M. Vail and Douglas H. ThammGENETICALLY ENGINEERED MOUSE MODELS OF CANCER16. Genetically Engineered Mouse Models of Pancreatic Ductal AdenocarcinomaAram F. Hezel and Nabeel Bardeesy17. Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP): A Validated Model for the Identification and Characterization of Mo...
