Post-Traumatic Stress Disorder - Basic Science and Clinical Practice

Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. The trauma can be due to war, terrorism, torture, natural disasters, violence, or rape. In PTSD the brain areas that are likely to be affected are the hippocampus (memory), amygdala (fear association), the prefrontal cortex (cognitive processing), and the ascending reticular activating system (arousal). The chemical of interest is norepinephrine, which is released during a stressful event and is part of the fight-or-flight response meant to mobilize the body to action.The objective of this title is to outline the neurobiology of post-traumatic stress disorder and provide treatment strategies for clinicians. The chapter material from this book has evolved from a seminar on PTSD held recently under the auspices of the VA Boston Healthcare System, Boston University Medical Center and Harvard Medical School.  We propose a book that will focus on the epidemiology, neurobiology, MRI studies, animal models, arousal and sleep issues, clinical trials, and treatment strategies for clinicians. Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD. This collection will be a vital source of information to clinicians and neuroscientists.

List of contents

Amygdala and Fear.- Post-Traumatic Stress Disorder: Definition, Prevalence, and Risk Factors.- The Amygdala and the Neural Pathways of Fear.- Physiology of the Amygdala: Implications for PTSD.- Counteracting Molecular Pathways Regulating the Reduction of Fear: Implications for the Treatment of Anxiety Diseases.- Memory in PTSD:A Neurocognitive Approach.- Animal Models of Post-Traumatic Stress Disorder.- Toward Animal Models of Post-Traumatic Stress Disorder.- PTSD: From Neurons to Networks.- Post-Traumatic Stress Disorder and Arousal.- Arousal Neurons in the Brain.- Hyperarousal and Post-Traumatic Stress Disorder: A Role for the Hypocretin System.- The Locus Coeruleus-Noradrenergic System and Stress: Implications for Post-Traumatic Stress Disorder.- Effect of Stress on Sleep and Its Relationship to Post-Traumatic Stress Disorder.- Stress hormones in post-traumatic stress disorder.- Stress Hormones and PTSD.- Low Basal Cortisol and Startle Responding as Possible Biomarkers of PTSD: The Influence of Internalizing and Externalizing Comorbidity.- Brain Imaging in Post-Traumatic Stress Disorder.- Functional Neuroimaging in Post-Traumatic Stress Disorder.- The Amygdala in Post-Traumatic Stress Disorder.- Treatment Strategies.- Pharmacologic Treatment of PTSD.- Guided Imagery as a Therapeutic Tool in Post-Traumatic Stress Disorder.- Virtual Reality Exposure Therapy for Combat-Related PTSD.

About the author

Joseph LeDoux ist Professor am Center for Neural Science an der New York University.

Summary

Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD.

Additional text

From the reviews:
"This book uses a variety of authors to review various aspects of the diagnosis, physiology, neurobiology, evaluation, and treatment of PTSD. … an invaluable resource for all clinicians and neuroscientists concerned with the condition. … Chapters end with an extensive list of current and relevant references, and numerous illustrations, diagrams, and figures … highlight salient features of the discussions. … It is well written, and the diagrams and illustrations provide appropriate visual representations of the important major points." (Steven T. Herron, Doody’s Review Service, September, 2009)
“Peter Shiromani … produce a book that will have much to offer both clinicians and investigators in the field of sleep. … provide a clear and comprehensive overview of the mechanisms of normal sleep-wake control that are likely to malfunction in PTSD. … Post-Traumatic Stress Disorder should be seen as a landmark in the joining of the PTSD and sleep fields.” (Richard J. Ross, Sleep, Vol. 32 (12), 2010)
“This is a worthwhile volume that will surely be useful in a new age of books that attempt, as this one does, to identify and apply the basic and applied science of PTSD. … Post-Traumatic Stress Disorder: Basic Science and Clinical Practice represents a growing and welcomed interest in PTSD among fields outside mental health practice, and it is consistent with the movement toward viewing traumatic consequences in terms of injury and recovery … .” (Charles R. Figley, PsycCRITIQUES, Vol. 55 (14), April, 2010)
“This is an exceptionally well-written and edited text, with a fine selection of chapter authors. … most suited to graduate students or postgraduate researchers who have an interest in conducting basic science or clinical trials for further understanding of underlying processes or treatments for PTSD. … I highly recommend Post-Traumatic Stress Disorder: Basic Science and ClinicalPractice for graduate students or postgraduate neuroscience researchers and university-based psychiatrists interested in expanding their research into basic science studies or clinical trials.” (Thomas Allen Grieger, Journal of the American Medical Association, Vol. 303 (19), May, 2010)

Report

From the reviews:
"This book uses a variety of authors to review various aspects of the diagnosis, physiology, neurobiology, evaluation, and treatment of PTSD. ... an invaluable resource for all clinicians and neuroscientists concerned with the condition. ... Chapters end with an extensive list of current and relevant references, and numerous illustrations, diagrams, and figures ... highlight salient features of the discussions. ... It is well written, and the diagrams and illustrations provide appropriate visual representations of the important major points." (Steven T. Herron, Doody's Review Service, September, 2009)
"Peter Shiromani ... produce a book that will have much to offer both clinicians and investigators in the field of sleep. ... provide a clear and comprehensive overview of the mechanisms of normal sleep-wake control that are likely to malfunction in PTSD. ... Post-Traumatic Stress Disorder should be seen as a landmark in the joining of the PTSD and sleep fields." (Richard J. Ross, Sleep, Vol. 32 (12), 2010)
"This is a worthwhile volume that will surely be useful in a new age of books that attempt, as this one does, to identify and apply the basic and applied science of PTSD. ... Post-Traumatic Stress Disorder: Basic Science and Clinical Practice represents a growing and welcomed interest in PTSD among fields outside mental health practice, and it is consistent with the movement toward viewing traumatic consequences in terms of injury and recovery ... ." (Charles R. Figley, PsycCRITIQUES, Vol. 55 (14), April, 2010)
"This is an exceptionally well-written and edited text, with a fine selection of chapter authors. ... most suited to graduate students or postgraduate researchers who have an interest in conducting basic science or clinical trials for further understanding of underlying processes or treatments for PTSD. ... I highly recommend Post-Traumatic Stress Disorder: Basic Science and ClinicalPractice for graduate students or postgraduate neuroscience researchers and university-based psychiatrists interested in expanding their research into basic science studies or clinical trials." (Thomas Allen Grieger, Journal of the American Medical Association, Vol. 303 (19), May, 2010)

Product details

• Authors: Peter Keane Shiromani
• Assisted by: Joseph E LeDoux (Editor), Terrenc Keane (Editor), Terrence Keane (Editor), Joseph E. Ledoux (Editor), Peter Shiromani (Editor)
• Publisher: Humana Press
• Languages: English
• Product format: Paperback / Softback
• Released: 31.03.2014
• EAN: 9781627038041
• ISBN: 978-1-62703-804-1
• No. of pages: 434
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; B, Medicine, Neurology, Neuroscience, Psychiatry, Neurosciences