Cellular Senescence and Tumor Suppression

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

List of contents

Senescence signals.- Telomere Biology and Biochemistry.- Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance.- Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses.- Stress-Induced Senescence.- The senescent phenotype.- The Secretome of Senescent Cells.- Chromatin Structure in Senescent Cells.- A Comparison of Senescence in Mouse and Human Cells.- The physiological consequences of senescence.- Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism.- Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging.- Mining Cellular Senescence for Drug Targets.

Summary

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Product details

• Assisted by: Peter D. Adams (Editor), Pete D Adams (Editor), Peter D Adams (Editor), M Sedivy (Editor), M Sedivy (Editor), John M. Sedivy (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2014
• EAN: 9781489983565
• ISBN: 978-1-4899-8356-5
• No. of pages: 272
• Dimensions: 155 mm x 15 mm x 235 mm
• Weight: 444 g
• Illustrations: XIII, 272 p. With 1 4-color insert.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; B, Pharmacology, Human Genetics, Biomedical and Life Sciences, Cancer Research, Medical Genetics, Biomedical Research, Pharmacology/Toxicology